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Review

Roles of ncRNAs as ceRNAs in Gastric Cancer

by 1, 2 and 1,*
1
State Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400716, China
2
College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400716, China
*
Author to whom correspondence should be addressed.
Academic Editor: Deborah J. Good
Genes 2021, 12(7), 1036; https://doi.org/10.3390/genes12071036
Received: 25 May 2021 / Revised: 28 June 2021 / Accepted: 28 June 2021 / Published: 2 July 2021
(This article belongs to the Special Issue Non-coding RNAs in Human Health and Diseases)
Although ignored in the past, with the recent deepening of research, significant progress has been made in the field of non-coding RNAs (ncRNAs). Accumulating evidence has revealed that microRNA (miRNA) response elements regulate RNA. Long ncRNAs, circular RNAs, pseudogenes, miRNAs, and messenger RNAs (mRNAs) form a competitive endogenous RNA (ceRNA) network that plays an essential role in cancer and cardiovascular, neurodegenerative, and autoimmune diseases. Gastric cancer (GC) is one of the most common cancers, with a high degree of malignancy. Considerable progress has been made in understanding the molecular mechanism and treatment of GC, but GC’s mortality rate is still high. Studies have shown a complex ceRNA crosstalk mechanism in GC. lncRNAs, circRNAs, and pseudogenes can interact with miRNAs to affect mRNA transcription. The study of the involvement of ceRNA in GC could improve our understanding of GC and lead to the identification of potential effective therapeutic targets. The research strategy for ceRNA is mainly to screen the different miRNAs, lncRNAs, circRNAs, pseudogenes, and mRNAs in each sample through microarray or sequencing technology, predict the ceRNA regulatory network, and, finally, conduct functional research on ceRNA. In this review, we briefly discuss the proposal and development of the ceRNA hypothesis and the biological function and principle of ceRNAs in GC, and briefly introduce the role of ncRNAs in the GC’s ceRNA network. View Full-Text
Keywords: non-coding RNAs; competitive endogenous RNA; gastric cancer non-coding RNAs; competitive endogenous RNA; gastric cancer
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MDPI and ACS Style

Ye, J.; Li, J.; Zhao, P. Roles of ncRNAs as ceRNAs in Gastric Cancer. Genes 2021, 12, 1036. https://doi.org/10.3390/genes12071036

AMA Style

Ye J, Li J, Zhao P. Roles of ncRNAs as ceRNAs in Gastric Cancer. Genes. 2021; 12(7):1036. https://doi.org/10.3390/genes12071036

Chicago/Turabian Style

Ye, Junhong, Jifu Li, and Ping Zhao. 2021. "Roles of ncRNAs as ceRNAs in Gastric Cancer" Genes 12, no. 7: 1036. https://doi.org/10.3390/genes12071036

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