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Role of Histone Methylation in Maintenance of Genome Integrity

1
Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar 190006, Jammu and Kashmir, India
2
Houston Methodist Research Institute, Houston, TX 77030, USA
3
Division of Hematology and Medical Oncology, Saint Louis University, St. Louis, MO 63110, USA
4
Centre for Molecular Biology, Central University of Jammu, Bagla 181143, Jammu and Kashmir, India
5
Centre for Interdisciplinary Research and Innovations, University of Kashmir, Srinagar 190006, Jammu and Kashmir, India
6
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Albert Jordan
Genes 2021, 12(7), 1000; https://doi.org/10.3390/genes12071000
Received: 17 May 2021 / Revised: 15 June 2021 / Accepted: 22 June 2021 / Published: 29 June 2021
Packaging of the eukaryotic genome with histone and other proteins forms a chromatin structure that regulates the outcome of all DNA mediated processes. The cellular pathways that ensure genomic stability detect and repair DNA damage through mechanisms that are critically dependent upon chromatin structures established by histones and, particularly upon transient histone post-translational modifications. Though subjected to a range of modifications, histone methylation is especially crucial for DNA damage repair, as the methylated histones often form platforms for subsequent repair protein binding at damaged sites. In this review, we highlight and discuss how histone methylation impacts the maintenance of genome integrity through effects related to DNA repair and repair pathway choice. View Full-Text
Keywords: histone methylation; DNA repair; homologous recombination; non-homologous end joining histone methylation; DNA repair; homologous recombination; non-homologous end joining
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MDPI and ACS Style

Mushtaq, A.; Mir, U.S.; Hunt, C.R.; Pandita, S.; Tantray, W.W.; Bhat, A.; Pandita, R.K.; Altaf, M.; Pandita, T.K. Role of Histone Methylation in Maintenance of Genome Integrity. Genes 2021, 12, 1000. https://doi.org/10.3390/genes12071000

AMA Style

Mushtaq A, Mir US, Hunt CR, Pandita S, Tantray WW, Bhat A, Pandita RK, Altaf M, Pandita TK. Role of Histone Methylation in Maintenance of Genome Integrity. Genes. 2021; 12(7):1000. https://doi.org/10.3390/genes12071000

Chicago/Turabian Style

Mushtaq, Arjamand, Ulfat S. Mir, Clayton R. Hunt, Shruti Pandita, Wajahat W. Tantray, Audesh Bhat, Raj K. Pandita, Mohammad Altaf, and Tej K. Pandita. 2021. "Role of Histone Methylation in Maintenance of Genome Integrity" Genes 12, no. 7: 1000. https://doi.org/10.3390/genes12071000

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