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A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes

Institute of Molecular Genetics of National Research Centre, “Kurchatov Institute”, 123182 Moscow, Russia
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Author to whom correspondence should be addressed.
The authors are contributed equally to this work.
Academic Editor: Isabella Ceccherini
Genes 2021, 12(3), 328; https://doi.org/10.3390/genes12030328
Received: 7 January 2021 / Revised: 21 February 2021 / Accepted: 21 February 2021 / Published: 25 February 2021
(This article belongs to the Section Human Genomics and Genetic Diseases)
In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on their expression as well. View Full-Text
Keywords: single nucleotide polymorphisms; models of brain ischemia; human orthologues; ischemic stroke single nucleotide polymorphisms; models of brain ischemia; human orthologues; ischemic stroke
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MDPI and ACS Style

Khvorykh, G.; Khrunin, A.; Filippenkov, I.; Stavchansky, V.; Dergunova, L.; Limborska, S. A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes. Genes 2021, 12, 328. https://doi.org/10.3390/genes12030328

AMA Style

Khvorykh G, Khrunin A, Filippenkov I, Stavchansky V, Dergunova L, Limborska S. A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes. Genes. 2021; 12(3):328. https://doi.org/10.3390/genes12030328

Chicago/Turabian Style

Khvorykh, Gennady, Andrey Khrunin, Ivan Filippenkov, Vasily Stavchansky, Lyudmila Dergunova, and Svetlana Limborska. 2021. "A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes" Genes 12, no. 3: 328. https://doi.org/10.3390/genes12030328

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