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Biological Regulatory Network (BRN) Analysis and Molecular Docking Simulations to Probe the Modulation of IP3R Mediated Ca2+ Signaling in Cancer
Open AccessReview

Role of Sigma-1 Receptor in Calcium Modulation: Possible Involvement in Cancer

UMR 1282, INSERM, Laboratoire de Biologie et Pharmacologie Appliquée, Ecole Normale Supérieure Paris Saclay, 91190 Gif Sur Yvette, France
Faculté des Sciences, Université Paris-Saclay, 91405 Orsay, France
Author to whom correspondence should be addressed.
Genes 2021, 12(2), 139;
Received: 18 December 2020 / Revised: 15 January 2021 / Accepted: 19 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Calcium Signalling in Cancer)
Ca2+ signaling plays a pivotal role in the control of cellular homeostasis and aberrant regulation of Ca2+ fluxes have a strong impact on cellular functioning. As a consequence of this ubiquitous role, Ca2+ signaling dysregulation is involved in the pathophysiology of multiple diseases including cancer. Indeed, multiple studies have highlighted the role of Ca2+ fluxes in all the steps of cancer progression. In particular, the transfer of Ca2+ at the ER-mitochondrial contact sites, also known as mitochondrial associated membranes (MAMs), has been shown to be crucial for cancer cell survival. One of the proteins enriched at this site is the sigma-1 receptor (S1R), a protein that has been described as a Ca2+-sensitive chaperone that exerts a protective function in cells in various ways, including the modulation of Ca2+ signaling. Interestingly, S1R is overexpressed in many types of cancer even though the exact mechanisms by which it promotes cell survival are not fully elucidated. This review summarizes the findings describing the roles of S1R in the control of Ca2+ signaling and its involvement in cancer progression. View Full-Text
Keywords: Ca2+ signalling; Sigma-1 receptor; cancer Ca2+ signalling; Sigma-1 receptor; cancer
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MDPI and ACS Style

Pontisso, I.; Combettes, L. Role of Sigma-1 Receptor in Calcium Modulation: Possible Involvement in Cancer. Genes 2021, 12, 139.

AMA Style

Pontisso I, Combettes L. Role of Sigma-1 Receptor in Calcium Modulation: Possible Involvement in Cancer. Genes. 2021; 12(2):139.

Chicago/Turabian Style

Pontisso, Ilaria; Combettes, Laurent. 2021. "Role of Sigma-1 Receptor in Calcium Modulation: Possible Involvement in Cancer" Genes 12, no. 2: 139.

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