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Article

Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells

1
Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
2
Department of Radiation Oncology, Saarland University Hospital, 66421 Homburg/Saar, Germany
3
Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91190 Gif-sur-Yvette, France
*
Authors to whom correspondence should be addressed.
The authors contribute equally.
Academic Editor: Albert Jordan
Genes 2021, 12(11), 1665; https://doi.org/10.3390/genes12111665
Received: 28 September 2021 / Revised: 18 October 2021 / Accepted: 19 October 2021 / Published: 22 October 2021
(This article belongs to the Section Molecular Genetics and Genomics)
H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer. View Full-Text
Keywords: histone variant H2A.J; luminal breast cancer; luminal prostate cancer; cancer biomarker; H2AFJ; H2AJ; estrogen-responsive genes histone variant H2A.J; luminal breast cancer; luminal prostate cancer; cancer biomarker; H2AFJ; H2AJ; estrogen-responsive genes
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MDPI and ACS Style

Redon, C.E.; Schmal, Z.; Tewary, G.; Mangelinck, A.; Courbeyrette, R.; Thuret, J.-Y.; Aladjem, M.I.; Bonner, W.M.; Rübe, C.E.; Mann, C. Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells. Genes 2021, 12, 1665. https://doi.org/10.3390/genes12111665

AMA Style

Redon CE, Schmal Z, Tewary G, Mangelinck A, Courbeyrette R, Thuret J-Y, Aladjem MI, Bonner WM, Rübe CE, Mann C. Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells. Genes. 2021; 12(11):1665. https://doi.org/10.3390/genes12111665

Chicago/Turabian Style

Redon, Christophe E., Zoe Schmal, Gargi Tewary, Adèle Mangelinck, Régis Courbeyrette, Jean-Yves Thuret, Mirit I. Aladjem, William M. Bonner, Claudia E. Rübe, and Carl Mann. 2021. "Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells" Genes 12, no. 11: 1665. https://doi.org/10.3390/genes12111665

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