Next Article in Journal
Prevalence and Spectrum of BRCA Germline Variants in Central Italian High Risk or Familial Breast/Ovarian Cancer Patients: A Monocentric Study
Previous Article in Journal
Multifaceted Roles of DNA Methylation in Neoplastic Transformation, from Tumor Suppressors to EMT and Metastasis
Previous Article in Special Issue
Cortical Granule Distribution and Expression Pattern of Genes Regulating Cellular Component Size, Morphogenesis, and Potential to Differentiation are Related to Oocyte Developmental Competence and Maturational Capacity In Vivo and In Vitro
Open AccessArticle

Progesterone Receptor Coregulators as Factors Supporting the Function of the Corpus Luteum in Cows

Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10–747 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Genes 2020, 11(8), 923; https://doi.org/10.3390/genes11080923
Received: 5 July 2020 / Revised: 6 August 2020 / Accepted: 7 August 2020 / Published: 12 August 2020
(This article belongs to the Special Issue Genomic Studies in the Mammalian Ovary)
Progesterone receptor (PGR) for its action required connection of the coregulatory proteins, including coactivators and corepressors. The former group exhibits a histone acetyltransferase (HAT) activity, while the latter cooperates with histone deacetylase (HDAC). Regulations of the coregulators mRNA and protein and HAT and HDAC activity can have an indirect effect on the PGR function and thus progesterone (P4) action on target cells. The highest mRNA expression levels for the coactivators—histone acetyltransferase p300 (P300), cAMP response element-binding protein (CREB), and steroid receptor coactivator-1 (SRC-1)—and nuclear receptor corepressor-2 (NCOR-2) were found in the corpus luteum (CL) on days 6 to 16 of the estrous cycle. The CREB protein level was higher on days 2–10, whereas SRC-1 and NCOR-2 were higher on days 2–5. The activity of HAT and HDAC was higher on days 6–10 of the estrous cycle. All of the coregulators were localized in the nuclei of small and large luteal cells. The mRNA and protein expression levels of the examined coactivators and corepressor changed with the P4 level. Thus, P4 may regulate CL function via the expression of coregulators, which probably affects the activity of the PGR. View Full-Text
Keywords: progesterone receptor coregulators; P300; CREB; SRC-1; NCOR-2; corpus luteum; cow progesterone receptor coregulators; P300; CREB; SRC-1; NCOR-2; corpus luteum; cow
Show Figures

Figure 1

MDPI and ACS Style

Rekawiecki, R.; Dobrzyn, K.; Kotwica, J.; Kowalik, M.K. Progesterone Receptor Coregulators as Factors Supporting the Function of the Corpus Luteum in Cows. Genes 2020, 11, 923.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop