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CDK Regulation of Meiosis: Lessons from S. cerevisiae and S. pombe

Department of Biology, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA
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Genes 2020, 11(7), 723; https://doi.org/10.3390/genes11070723
Received: 16 May 2020 / Revised: 26 June 2020 / Accepted: 26 June 2020 / Published: 29 June 2020
(This article belongs to the Special Issue Chromosome Segregation Defects in the Origin of Genomic Instability)
Meiotic progression requires precise orchestration, such that one round of DNA replication is followed by two meiotic divisions. The order and timing of meiotic events is controlled through the modulation of the phosphorylation state of proteins. Key components of this phospho-regulatory system include cyclin-dependent kinase (CDK) and its cyclin regulatory subunits. Over the past two decades, studies in budding and fission yeast have greatly informed our understanding of the role of CDK in meiotic regulation. In this review, we provide an overview of how CDK controls meiotic events in both budding and fission yeast. We discuss mechanisms of CDK regulation through post-translational modifications and changes in the levels of cyclins. Finally, we highlight the similarities and differences in CDK regulation between the two yeast species. Since CDK and many meiotic regulators are highly conserved, the findings in budding and fission yeasts have revealed conserved mechanisms of meiotic regulation among eukaryotes. View Full-Text
Keywords: meiosis; Cyclin-Dependent Kinase; CDK; cyclin; APC/C; budding yeast; fission yeast; chromosome segregation meiosis; Cyclin-Dependent Kinase; CDK; cyclin; APC/C; budding yeast; fission yeast; chromosome segregation
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MacKenzie, A.M.; Lacefield, S. CDK Regulation of Meiosis: Lessons from S. cerevisiae and S. pombe. Genes 2020, 11, 723.

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