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Reciprocal Regulation between Primary Cilia and mTORC1

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
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Genes 2020, 11(6), 711; https://doi.org/10.3390/genes11060711
Received: 30 May 2020 / Revised: 22 June 2020 / Accepted: 24 June 2020 / Published: 26 June 2020
(This article belongs to the Special Issue Cellular Growth Control by TOR Signaling)
In quiescent cells, primary cilia function as a mechanosensor that converts mechanic signals into chemical activities. This unique organelle plays a critical role in restricting mechanistic target of rapamycin complex 1 (mTORC1) signaling, which is essential for quiescent cells to maintain their quiescence. Multiple mechanisms have been identified that mediate the inhibitory effect of primary cilia on mTORC1 signaling. These mechanisms depend on several tumor suppressor proteins localized within the ciliary compartment, including liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK), polycystin-1, and polycystin-2. Conversely, changes in mTORC1 activity are able to affect ciliogenesis and stability indirectly through autophagy. In this review, we summarize recent advances in our understanding of the reciprocal regulation of mTORC1 and primary cilia. View Full-Text
Keywords: primary cilia; mTOR; mTORC1; autophagy; ciliogenesis; Tsc2; polycystin-1; LKB1; AMPK primary cilia; mTOR; mTORC1; autophagy; ciliogenesis; Tsc2; polycystin-1; LKB1; AMPK
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Lai, Y.; Jiang, Y. Reciprocal Regulation between Primary Cilia and mTORC1. Genes 2020, 11, 711.

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