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Open AccessArticle

Domesticated gag Gene of Drosophila LTR Retrotransposons Is Involved in Response to Oxidative Stress

1
Laboratory of Exercise Physiology, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow 123007, Russia
2
Department of Genetics, Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia
*
Author to whom correspondence should be addressed.
Genes 2020, 11(4), 396; https://doi.org/10.3390/genes11040396
Received: 11 March 2020 / Revised: 29 March 2020 / Accepted: 1 April 2020 / Published: 6 April 2020
Drosophila melanogaster is one of the most extensively used genetic model organisms for studying LTR retrotransposons that are represented by various groups in its genome. However, the phenomenon of molecular domestication of LTR retrotransposons has been insufficiently studied in Drosophila, as well as in other invertebrates. The present work is devoted to studying the role of the domesticated gag gene, Gagr, in the Drosophila genome. The Gagr gene has been shown to be involved in the response to stress caused by exposure to ammonium persulfate, but not in the stress response to oligomycin A, zeomycin, and cadmium chloride. Ammonium persulfate tissue specifically activates the expression of Gagr in the tissues of the carcass, but not in the gut. We found that the Gagr gene promoter contains one binding motif for the transcription factor kayak, a component of the JNK signaling pathway, and two binding motifs for the transcription factor Stat92E, a component of the Jak-STAT signaling pathway. Remarkably, Gagr orthologs contain the second binding motif for Stat92E only in D. melanogaster, D. simulans and D. sechellia, whereas in D. yakuba and D. erecta, Gagr orthologs contain a single motif, and there are no binding sites for Stat92E in the promoters of Gagr orthologs in D. ananassae and in species outside the melanogaster group. The data obtained indicate the formation of the protective function of the Gagr gene during evolution. View Full-Text
Keywords: Drosophila; LTR retrotransposon; molecular domestication; evolution; stress Drosophila; LTR retrotransposon; molecular domestication; evolution; stress
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MDPI and ACS Style

Makhnovskii, P.; Balakireva, Y.; Nefedova, L.; Lavrenov, A.; Kuzmin, I.; Kim, A. Domesticated gag Gene of Drosophila LTR Retrotransposons Is Involved in Response to Oxidative Stress. Genes 2020, 11, 396. https://doi.org/10.3390/genes11040396

AMA Style

Makhnovskii P, Balakireva Y, Nefedova L, Lavrenov A, Kuzmin I, Kim A. Domesticated gag Gene of Drosophila LTR Retrotransposons Is Involved in Response to Oxidative Stress. Genes. 2020; 11(4):396. https://doi.org/10.3390/genes11040396

Chicago/Turabian Style

Makhnovskii, Pavel; Balakireva, Yevheniia; Nefedova, Lidia; Lavrenov, Anton; Kuzmin, Ilya; Kim, Alexander. 2020. "Domesticated gag Gene of Drosophila LTR Retrotransposons Is Involved in Response to Oxidative Stress" Genes 11, no. 4: 396. https://doi.org/10.3390/genes11040396

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