Next Article in Journal
New Transcriptome-Based SNP Markers for Noug (Guizotia abyssinica) and Their Conversion to KASP Markers for Population Genetics Analyses
Previous Article in Journal
At the X-Roads of Sex and Genetics in Pulmonary Arterial Hypertension
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Genes
Volume 11
Issue 11
10.3390/genes11111372
Review Report
genes-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Stem Cells: Current Status and Therapeutic Implications

Genes 2020, 11(11), 1372; https://doi.org/10.3390/genes11111372
by Kaladhar B. Reddy 1,2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Genes 2020, 11(11), 1372; https://doi.org/10.3390/genes11111372
Submission received: 21 September 2020 / Revised: 11 November 2020 / Accepted: 18 November 2020 / Published: 20 November 2020
(This article belongs to the Section Human Genomics and Genetic Diseases)

Round 1

Reviewer 1 Report

English revision recommended.

Cancer stem cells do have a distinctive metabolic phenotype which escapes conventional therapies. Please add a discussion on this. 

Please find the detailed comments in the attachment.

 

Comments for author File: Comments.pdf

Author Response

please see the authors' reply in the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

The review does not add anything to the literature on Cancer Stem cells. Some part appear to be written in hurry without any deeper consideration or explanation.

In the first paragraph on key features of normal and cancer stem cells, the Authors should expand the ability of both NSC and CSC to escape innate or adaptive immune system ( see also Pastò A et al IJMS, 2020). The sentence as such is not clear: the behavior of Normal stem cells is different from the one of cancer stem cells, since the immune microenvironment in which they reside is completely different. Explain in details, also in the paragraph of Immunological characteristics of cancer stem cells.

Please add clarification also to the sentence “quiescent most of the time”.

Please add reference to the abnormal karyotype and mitotically less active of CSC.

The whole structure of the review is difficult to follow: in the cancer stem cell’s niche the Authors describe immunological characteristics of cancer stem cells and the surrounding microenvironment that could be put together with the other aspect of CSCs described in the paragraph above.

Try to organize the structure of the review in a different manner.

A figure summarizing the similarities and differences between NSC and CSC should be added.

Figure 1 is not clear, it needed to be better explained in the text

Typing and grammar errors in the metastatic cancer stem cells paragraph.

Author Response

please see the authors' reply in the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

the Authors addressed all the points asked by the reviewer 

 

 

Back to TopTop