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Genes 2019, 10(4), 254; https://doi.org/10.3390/genes10040254

Identifying Selection Signatures for Backfat Thickness in Yorkshire Pigs Highlights New Regions Affecting Fat Metabolism

Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education & Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China
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Received: 18 February 2019 / Revised: 23 March 2019 / Accepted: 26 March 2019 / Published: 28 March 2019
(This article belongs to the Section Animal Genetics and Genomics)
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Abstract

Identifying the genetic basis of improvement in pigs contributes to our understanding of the role of artificial selection in shaping the genome. Here we employed the Cross Population Extended Haplotype Homozogysity (XPEHH) and the Wright’s fixation index (FST) methods to detect trait-specific selection signatures by making phenotypic gradient differential population pairs, and then attempted to map functional genes of six backfat thickness traits in Yorkshire pigs. The results indicate that a total of 283 and 466 single nucleotide polymorphisms (SNPs) were identified as trait-specific selection signatures using FST and XPEHH, respectively. Functional annotation suggested that the genes overlapping with the trait-specific selection signatures such as OSBPL8, ASAH2, SMCO2, GBE1, and ABL1 are responsible for the phenotypes including fat metabolism, lean body mass and fat deposition, and transport in mouse. Overall, the study developed the methods of gene mapping on the basis of identification of selection signatures. The candidate genes putatively associated with backfat thickness traits can provide important references and fundamental information for future pig-breeding programs. View Full-Text
Keywords: trait-specific selection signatures; population differentiation-based methods; functional annotation trait-specific selection signatures; population differentiation-based methods; functional annotation
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Ma, H.; Zhang, S.; Zhang, K.; Zhan, H.; Peng, X.; Xie, S.; Li, X.; Zhao, S.; Ma, Y. Identifying Selection Signatures for Backfat Thickness in Yorkshire Pigs Highlights New Regions Affecting Fat Metabolism. Genes 2019, 10, 254.

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