The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer
Abstract
:1. Introduction
2. Chaperone-Mediated Autophagy (CMA)
3. Physiological and Pathological Roles of CMA
4. CMA’s Role in Cancer
4.1. Anti-Tumor Functions of CMA
4.2. Pro-Tumor Functions of CMA
5. CMA Control of Cell Cycle in Distinct Cellular Contexts
5.1. Tumor Transformation: MYC
5.2. Hypoxia: HIF-1α
5.3. DNA Damage Response: CHK1
5.4. Different Tumor Cell Models: p73, RND3, and Cyclin D1
6. Conclusions and Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Andrade-Tomaz, M.; de Souza, I.; Rocha, C.R.R.; Gomes, L.R. The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer. Cells 2020, 9, 2140. https://doi.org/10.3390/cells9092140
Andrade-Tomaz M, de Souza I, Rocha CRR, Gomes LR. The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer. Cells. 2020; 9(9):2140. https://doi.org/10.3390/cells9092140
Chicago/Turabian StyleAndrade-Tomaz, Marina, Izadora de Souza, Clarissa Ribeiro Reily Rocha, and Luciana Rodrigues Gomes. 2020. "The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer" Cells 9, no. 9: 2140. https://doi.org/10.3390/cells9092140