Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability
Abstract
:1. Introduction
2. Biomarkers Related to Hypoxia Regulation in Normal Tissues
3. Normal Bone and Hypoxia: Involvement in Osseous Production and Formation and Osteoclast-Mediated Bone Resorption
4. Presence of Hypoxic Biomarkers in Osteosarcomas Is Related to Progression and Resistance to Treatment
5. Immune Response, Hypoxia and Osteosarcoma Cells
6. HIFs Targeting in OTS
7. In Vitro and In Vivo Models to Recreate OTS Hypoxic Microenvironment
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Pierrevelcin, M.; Fuchs, Q.; Lhermitte, B.; Messé, M.; Guérin, E.; Weingertner, N.; Martin, S.; Lelong-Rebel, I.; Nazon, C.; Dontenwill, M.; et al. Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability. Cells 2020, 9, 1998. https://doi.org/10.3390/cells9091998
Pierrevelcin M, Fuchs Q, Lhermitte B, Messé M, Guérin E, Weingertner N, Martin S, Lelong-Rebel I, Nazon C, Dontenwill M, et al. Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability. Cells. 2020; 9(9):1998. https://doi.org/10.3390/cells9091998
Chicago/Turabian StylePierrevelcin, Marina, Quentin Fuchs, Benoit Lhermitte, Melissa Messé, Eric Guérin, Noelle Weingertner, Sophie Martin, Isabelle Lelong-Rebel, Charlotte Nazon, Monique Dontenwill, and et al. 2020. "Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability" Cells 9, no. 9: 1998. https://doi.org/10.3390/cells9091998