Molecular and Mechanobiological Pathways Related to the Physiopathology of FPLD2
Abstract
:1. Introduction
2. Signaling Pathways Affected by FPLD2-Associated LMNA Mutations That Contribute to the Onset of MD and Cardiovascular Disease
2.1. Abnormal Sequestration of the Transcription Factors SREBP1 and Sp1, Caused by FPLD2-Associated LMNA Mutations, Inhibits Adipocytic Differentiation
2.2. Altered Adipocytic Differentiation Is Triggered by a Misregulation of the Notch and Wnt/β-Catenin Pathways
2.3. Overexpression of miR-335 Driven by FPLD2-Associated LMNA Mutations Interferes with Adipocytic Differentiation
2.4. Accumulation of Prelamin A: A Path to the Premature Senescence of MSCs and Vascular Cells
2.5. Potential Targets to Explore in the Physiopathology of MD in the Context of FPLD2 Associated with LMNA Mutations
2.6. Can the Biology of Adipose Tissue Explain the Physiopathology of FPLD2?
3. A Link between MDs and Cardiovascular Diseases and the Alteration of the Mechanobiological Response of Stem and Vascular Cells
3.1. Changes of the MSCs’ Mechanoresponse Induced by FPLD2-Associated LMNA Mutations Inhibit Adipocytic Differentiation
3.2. LMNA Mutations Associated with FPLD2 Physiopathology Interfere with the Precise Response of Vascular Cells to Shear Stress
4. Microfluidic Tools to Investigate Alterations of the Cellular Mechanical Properties Induced by FPLD2-Associated LMNA Mutations
4.1. Powerful Tools for Assessing Cell Mechanicanical Properties Based on Their Capacity to Deform Themselves or Their Environment
4.2. Towards an Easy Diagnosis for Metabolic Disorders Associated with LMNA Mutations
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Varlet, A.-A.; Helfer, E.; Badens, C. Molecular and Mechanobiological Pathways Related to the Physiopathology of FPLD2. Cells 2020, 9, 1947. https://doi.org/10.3390/cells9091947
Varlet A-A, Helfer E, Badens C. Molecular and Mechanobiological Pathways Related to the Physiopathology of FPLD2. Cells. 2020; 9(9):1947. https://doi.org/10.3390/cells9091947
Chicago/Turabian StyleVarlet, Alice-Anaïs, Emmanuèle Helfer, and Catherine Badens. 2020. "Molecular and Mechanobiological Pathways Related to the Physiopathology of FPLD2" Cells 9, no. 9: 1947. https://doi.org/10.3390/cells9091947