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Cells 2018, 7(2), 12;

MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages

Department of Immunology and Microbiology, the Scripps Research Institute, Jupiter, 33458 FL, USA
Received: 27 December 2017 / Revised: 1 February 2018 / Accepted: 6 February 2018 / Published: 8 February 2018
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Innate immune cells form an integrative component of the tumor microenvironment (TME), which can control or prevent tumor initiation and progression, due to the simultaneous processing of both anti- and pro-growth signals. This decision-making process is a consequence of gene expression changes, which are in part dependent on post-transcriptional regulatory mechanisms. In this context, microRNAs have been shown to regulate both recruitment and activation of specific tumor-associated immune cells in the TME. This review aims to describe the most important microRNAs that target cancer-related innate immune pathways. The role of exosomal microRNAs in tumor progression and microRNA-based therapeutic strategies are also discussed. View Full-Text
Keywords: microRNA; inflammation; cancer; macrophages microRNA; inflammation; cancer; macrophages

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Curtale, G. MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages. Cells 2018, 7, 12.

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