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Cells 2016, 5(2), 20;

Role of Intermediate Filaments in Vesicular Traffic

Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy
Author to whom correspondence should be addressed.
Academic Editor: Rudolf E. Leube
Received: 23 March 2016 / Revised: 13 April 2016 / Accepted: 20 April 2016 / Published: 25 April 2016
(This article belongs to the Special Issue Beyond Cell Mechanics: Novel Functions of Intermediate Filaments)
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Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway. View Full-Text
Keywords: intermediate filaments; intracellular trafficking; endocytosis; exocytosis; vimentin; membrane traffic; mitosis intermediate filaments; intracellular trafficking; endocytosis; exocytosis; vimentin; membrane traffic; mitosis

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Margiotta, A.; Bucci, C. Role of Intermediate Filaments in Vesicular Traffic. Cells 2016, 5, 20.

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