Next Article in Journal
Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis
Next Article in Special Issue
Form, Fabric, and Function of a Flagellum-Associated Cytoskeletal Structure
Previous Article in Journal
Active Nuclear Import of Membrane Proteins Revisited
Previous Article in Special Issue
Specialized Cilia in Mammalian Sensory Systems
Open AccessReview

Photoreceptor Sensory Cilium: Traversing the Ciliary Gate

Department of Ophthalmology, UMASS Medical School, Worcester, MA 01605, USA
Academic Editors: Gang Dong and William Tsang
Cells 2015, 4(4), 674-686; https://doi.org/10.3390/cells4040674
Received: 14 September 2015 / Revised: 7 October 2015 / Accepted: 9 October 2015 / Published: 15 October 2015
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
Cilia are antenna-like extensions of the plasma membrane found in nearly all cell types. In the retina of the eye, photoreceptors develop unique sensory cilia. Not much was known about the mechanisms underlying the formation and function of photoreceptor cilia, largely because of technical limitations and the specific structural and functional modifications that cannot be modeled in vitro. With recent advances in microscopy techniques and molecular and biochemical approaches, we are now beginning to understand the molecular basis of photoreceptor ciliary architecture, ciliary function and its involvement in human diseases. Here, I will discuss the studies that have revealed new knowledge of how photoreceptor cilia regulate their identity and function while coping with high metabolic and trafficking demands associated with processing light signal. View Full-Text
Keywords: cilia; flagella; ciliopathies; retina; retinopathies; transition zone; protein trafficking cilia; flagella; ciliopathies; retina; retinopathies; transition zone; protein trafficking
Show Figures

Graphical abstract

MDPI and ACS Style

Khanna, H. Photoreceptor Sensory Cilium: Traversing the Ciliary Gate. Cells 2015, 4, 674-686.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop