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Ciliary/Flagellar Protein Ubiquitination

Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
Author to whom correspondence should be addressed.
Academic Editors: William Tsang and Gang Dong
Cells 2015, 4(3), 474-482;
Received: 7 June 2015 / Accepted: 28 August 2015 / Published: 2 September 2015
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
Cilia/flagella are conserved eukaryotic organelles that play an important role in the control of cell motility and detection of environmental cues. However, the molecular mechanisms underlying ciliary/flagellar assembly, maintenance, disassembly, and signal transduction are not yet completely understood. Recent studies demonstrated that post-translational modifications (PTMs) such as phosphorylation, methylation, glutamylation, and ubiquitination are involved in these processes. In this mini review, we present a summary of research progress in ciliary/flagellar protein ubiquitination, including the ubiquitin conjugation system identified by proteomics as well as the role of ciliary/flagellar protein ubiquitination in flagellar disassembly, motility, and signal transduction. Moreover, we described putative further research directions in the study of ciliary/flagellar protein ubiquitination. View Full-Text
Keywords: flagella; ubiquitination; post-translational modifications; sperm; primary cilia flagella; ubiquitination; post-translational modifications; sperm; primary cilia
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MDPI and ACS Style

Long, H.; Wang, Q.; Huang, K. Ciliary/Flagellar Protein Ubiquitination. Cells 2015, 4, 474-482.

AMA Style

Long H, Wang Q, Huang K. Ciliary/Flagellar Protein Ubiquitination. Cells. 2015; 4(3):474-482.

Chicago/Turabian Style

Long, Huan, Qiyu Wang, and Kaiyao Huang. 2015. "Ciliary/Flagellar Protein Ubiquitination" Cells 4, no. 3: 474-482.

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