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Cells
Volume 14
Issue 21
10.3390/cells14211684
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Multi-Omics Analysis of the Potential Mechanisms of Skin Albinism in Edangered Percocypris pingi: Abnormal Ubiquitination and Calcium Signal Inhibition

by
Senyue Liu
1,2,
Xiaoyun Wu
1,
Qiaolin Zou
1,
Jiansheng Lai
1,
Luyun Ni
1,
Yongqiang Deng
1,2,
Yang Feng
1,2,
Mingjiang Song
1,
Pengcheng Li
1,
Jun Du
1,
Qiang Li
1,2 and
Ya Liu
1,*
1
Fisheries Research Institute, Sichuan Academy of Agricultural Sciences (Sichuan Fisheries Research Institute), Chengdu 611731, China
2
Aquatic Health and Intelligent Aquaculture Key Laboratory of Sichuan Province, Chengdu 611130, China
*
Author to whom correspondence should be addressed.
Cells 2025, 14(21), 1684; https://doi.org/10.3390/cells14211684 (registering DOI)
Submission received: 16 September 2025 / Revised: 22 October 2025 / Accepted: 24 October 2025 / Published: 27 October 2025
(This article belongs to the Topic Animal Models of Human Disease 3.0)
Versions Notes

Abstract

Percocypris pingi is an endangered protected fish species in China. Its albino variants exhibit growth retardation and physiological abnormalities. Understanding its albinism mechanism holds significant scientific importance for molecular breeding programs and disease model development. This study integrated transcriptomic and proteomic analyses, combined with histopathological and molecular biological techniques, to systematically compare molecular differences in skin tissues between albino and wild-type P. pingi, with a focus on elucidating the multidimensional regulatory mechanisms underlying skin albinism. Our findings suggest that albinism in P. pingi is synergistically driven by hyperactivation of ubiquitin-mediated proteolysis (which suppressed TYR/TYRP1 enzymatic activity and disrupted the pH homeostasis of melanosomes), and inhibition of calcium signaling (which impeded melanin transport). This discovery provides novel insights into the mechanisms of pigment loss in fish species and offers a valuable reference for molecular breeding of endangered species as well as research on pigmentation-related disorders.
Keywords: albinism; ubiquitination; calcium signaling; multi-omics; pigment albinism; ubiquitination; calcium signaling; multi-omics; pigment

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MDPI and ACS Style

Liu, S.; Wu, X.; Zou, Q.; Lai, J.; Ni, L.; Deng, Y.; Feng, Y.; Song, M.; Li, P.; Du, J.; et al. Multi-Omics Analysis of the Potential Mechanisms of Skin Albinism in Edangered Percocypris pingi: Abnormal Ubiquitination and Calcium Signal Inhibition. Cells 2025, 14, 1684. https://doi.org/10.3390/cells14211684

AMA Style

Liu S, Wu X, Zou Q, Lai J, Ni L, Deng Y, Feng Y, Song M, Li P, Du J, et al. Multi-Omics Analysis of the Potential Mechanisms of Skin Albinism in Edangered Percocypris pingi: Abnormal Ubiquitination and Calcium Signal Inhibition. Cells. 2025; 14(21):1684. https://doi.org/10.3390/cells14211684

Chicago/Turabian Style

Liu, Senyue, Xiaoyun Wu, Qiaolin Zou, Jiansheng Lai, Luyun Ni, Yongqiang Deng, Yang Feng, Mingjiang Song, Pengcheng Li, Jun Du, and et al. 2025. "Multi-Omics Analysis of the Potential Mechanisms of Skin Albinism in Edangered Percocypris pingi: Abnormal Ubiquitination and Calcium Signal Inhibition" Cells 14, no. 21: 1684. https://doi.org/10.3390/cells14211684

APA Style

Liu, S., Wu, X., Zou, Q., Lai, J., Ni, L., Deng, Y., Feng, Y., Song, M., Li, P., Du, J., Li, Q., & Liu, Y. (2025). Multi-Omics Analysis of the Potential Mechanisms of Skin Albinism in Edangered Percocypris pingi: Abnormal Ubiquitination and Calcium Signal Inhibition. Cells, 14(21), 1684. https://doi.org/10.3390/cells14211684

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