Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Substrate Switching Induces Mitochondrial Pathology in Cultured CMT2A Patient Fibroblasts
3.2. Mitofusin Activation Corrects Mitochondrial Pathology in CMT2A Patient Fibroblasts
3.3. Mitochondrial Respiratory Dysfunction in Parkinson’s Disease PARK R275W Fibroblasts Is Improved after Mitofusin Activation
3.4. Mitochondrial Pathology Is Variable in Fibroblasts from Alzheimer’s Diseases Individuals
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Dang, X.; Walton, E.K.; Zablocka, B.; Baloh, R.H.; Shy, M.E.; Dorn, G.W., II. Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation. Cells 2022, 11, 1053. https://doi.org/10.3390/cells11061053
Dang X, Walton EK, Zablocka B, Baloh RH, Shy ME, Dorn GW II. Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation. Cells. 2022; 11(6):1053. https://doi.org/10.3390/cells11061053
Chicago/Turabian StyleDang, Xiawei, Emily K. Walton, Barbara Zablocka, Robert H. Baloh, Michael E. Shy, and Gerald W. Dorn, II. 2022. "Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation" Cells 11, no. 6: 1053. https://doi.org/10.3390/cells11061053
APA StyleDang, X., Walton, E. K., Zablocka, B., Baloh, R. H., Shy, M. E., & Dorn, G. W., II. (2022). Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation. Cells, 11(6), 1053. https://doi.org/10.3390/cells11061053