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Cells
Volume 11
Issue 1
10.3390/cells11010110
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Mitochondrial Dysfunction as a Hallmark of Environmental Injury

by
Carolina Duarte-Hospital
1,2,†,
Arnaud Tête
1,2,†,
François Brial
1,
Louise Benoit
1,2,
Meriem Koual
1,2,
Céline Tomkiewicz
1,2,
Min Ji Kim
1,3,
Etienne B. Blanc
1,2,
Xavier Coumoul
1,2,*,‡ and
Sylvie Bortoli
1,2,*,‡
1
Environmental Toxicity, Therapeutic Targets, Cellular Signaling and Biomarkers, T3S, INSERM UMR-S 1124, F-75006 Paris, France
2
Faculty of Sciences, Université de Paris, F-75006 Paris, France
3
Université Sorbonne Paris Nord, F-93000 Bobigny, France
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Equal supervision.
Academic Editors: Natascia Ventura and Judith Haendeler
Cells 2022, 11(1), 110; https://doi.org/10.3390/cells11010110
Received: 30 November 2021 / Revised: 24 December 2021 / Accepted: 27 December 2021 / Published: 30 December 2021
(This article belongs to the Special Issue Role of Mitochondria in Environmentally and Dietary Modulated Age-Associated Diseases)
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Abstract

Environmental factors including diet, sedentary lifestyle and exposure to pollutants largely influence human health throughout life. Cellular and molecular events triggered by an exposure to environmental pollutants are extremely variable and depend on the age, the chronicity and the doses of exposure. Only a fraction of all relevant mechanisms involved in the onset and progression of pathologies in response to toxicants has probably been identified. Mitochondria are central hubs of metabolic and cell signaling responsible for a large variety of biochemical processes, including oxidative stress, metabolite production, energy transduction, hormone synthesis, and apoptosis. Growing evidence highlights mitochondrial dysfunction as a major hallmark of environmental insults. Here, we present mitochondria as crucial organelles for healthy metabolic homeostasis and whose dysfunction induces critical adverse effects. Then, we review the multiple mechanisms of action of pollutants causing mitochondrial toxicity in link with chronic diseases. We propose the Aryl hydrocarbon Receptor (AhR) as a model of “exposome receptor”, whose activation by environmental pollutants leads to various toxic events through mitochondrial dysfunction. Finally, we provide some remarks related to mitotoxicity and risk assessment. View Full-Text
Keywords: mitotoxicity; xenobiotics; environmental pollutants mitotoxicity; xenobiotics; environmental pollutants
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Duarte-Hospital, C.; Tête, A.; Brial, F.; Benoit, L.; Koual, M.; Tomkiewicz, C.; Kim, M.J.; Blanc, E.B.; Coumoul, X.; Bortoli, S. Mitochondrial Dysfunction as a Hallmark of Environmental Injury. Cells 2022, 11, 110. https://doi.org/10.3390/cells11010110

AMA Style

Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S. Mitochondrial Dysfunction as a Hallmark of Environmental Injury. Cells. 2022; 11(1):110. https://doi.org/10.3390/cells11010110

Chicago/Turabian Style

Duarte-Hospital, Carolina, Arnaud Tête, François Brial, Louise Benoit, Meriem Koual, Céline Tomkiewicz, Min J. Kim, Etienne B. Blanc, Xavier Coumoul, and Sylvie Bortoli. 2022. "Mitochondrial Dysfunction as a Hallmark of Environmental Injury" Cells 11, no. 1: 110. https://doi.org/10.3390/cells11010110

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