Next Article in Journal
The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress
Next Article in Special Issue
Trophic Actions of Bone Marrow-Derived Mesenchymal Stromal Cells for Muscle Repair/Regeneration
Previous Article in Journal / Special Issue
The Myc Road to Hearing Restoration
Open AccessReview

High Mobility Group Box Protein-1 in Wound Repair

Department of Sciences and Innovative Technology, (DiSIT), University of Piemonte Orientale "A. Avogadro", Viale Teresa Michel 11, Alessandria 15121, Italy
Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, Milan 20132, Italy
Department of Experimental Medicine (DIMES)-Biochemistry Section, Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, Genoa 1-16132, Italy
Author to whom correspondence should be addressed.
Cells 2012, 1(4), 699-710;
Received: 10 August 2012 / Revised: 10 September 2012 / Accepted: 19 September 2012 / Published: 28 September 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
PDF [289 KB, uploaded 28 September 2012]


High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor. Secreted extracellularly by activated monocytes and macrophages or passively released by necrotic or damaged cells, extracellular HMGB1 is a potent mediator of inflammation. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage), but it also activates and recruits stem cells, boosting tissue repair. Here, we focus on the role of HMGB1 in physiological and pathological responses, the mechanisms by which it contributes to tissue repair and therapeutic strategies base on targeting HMGB1. View Full-Text
Keywords: HMGB1; alarmin; DAMP; tissue repair; wound cytokine HMGB1; alarmin; DAMP; tissue repair; wound cytokine

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Ranzato, E.; Martinotti, S.; Pedrazzi, M.; Patrone, M. High Mobility Group Box Protein-1 in Wound Repair. Cells 2012, 1, 699-710.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top