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Polymers 2017, 9(8), 330; https://doi.org/10.3390/polym9080330

Development and In Vitro Evaluation of Lyotropic Liquid Crystals for the Controlled Release of Dexamethasone

1
School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, Brazil
2
School of Pharmaceutical Sciences, Federal University of Alfenas, UNIFAL-MG, 37130-000 Alfenas, Brazil
3
Human and Natural Sciences Center, Federal University of ABC, 09210-580 Santo André, Brazil
4
Instituto Interuniversitario Reconocimiento Molecular y Desarrollo Tecnológico, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Universidad de Valencia, 46010 Valencia, Spain
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 20 June 2017 / Revised: 26 July 2017 / Accepted: 30 July 2017 / Published: 2 August 2017
(This article belongs to the Special Issue Advance of Polymers Applied to Biomedical Applications: Biointerface)
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Abstract

In this study, amphiphilic polymers were investigated as biomaterials that can control dexamethasone (DXM) release. Such materials present interfacial properties in the presence of water and an oily phase that can result in lyotropic liquid crystalline systems (LLCS). In addition, they can form colloidal nanostructures similar to those in living organisms, such as bilayers and hexagonal and cubic phases, which can be exploited to solubilize lipophilic drugs to sustain their release and enhance bioavailability. It was possible to obtain lamellar and hexagonal phases when combining polyoxyethylene (20) cetyl ether (CETETH-20) polymer with oleic acid (OA), N-methylpyrrolidone (P), isopropyl myristate (IM), and water. The phases were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheological, textural, and bioadhesion analyses followed by an in vitro release assay. All samples showed elastic behavior in the rheology studies and hexagonal samples containing P and IM showed the highest adhesiveness. The drug release profile of all LLCS presented an average lag time of 3 h and was best fitted to the Korsmeyer-Peppas and Weibull models, with controlled release governed by a combination of diffusion and erosion mechanisms. These systems are potential carriers for DXM and can be explored in several routes of administration, providing potential advantages over conventional pharmaceutical forms. View Full-Text
Keywords: amphiphilic polymers; lyotropic liquid crystals; controlled release; drug release; kinetic model; dexamethasone; nanostructured systems amphiphilic polymers; lyotropic liquid crystals; controlled release; drug release; kinetic model; dexamethasone; nanostructured systems
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Oyafuso, M.H.; Carvalho, F.C.; Takeshita, T.M.; de Souza, A.L.R.; Araújo, D.R.; Merino, V.; Gremião, M.P.D.; Chorilli, M. Development and In Vitro Evaluation of Lyotropic Liquid Crystals for the Controlled Release of Dexamethasone. Polymers 2017, 9, 330.

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