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Poly(Lactic-co-Glycolic Acid): Applications and Future Prospects for Periodontal Tissue Regeneration

by Xiaoyu Sun 1,2,†, Chun Xu 3,†, Gang Wu 2, Qingsong Ye 3,* and Changning Wang 1,*,‡
1
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, China
2
Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam 1081 HV, The Netherlands
3
Laboratory of Regenerative Dentistry, School of Dentistry, The University of Queensland, Brisbane 4006, Australia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Changning Wang is the first corresponding author.
Academic Editor: Patrick van Rijn
Polymers 2017, 9(6), 189; https://doi.org/10.3390/polym9060189
Received: 11 April 2017 / Revised: 8 May 2017 / Accepted: 11 May 2017 / Published: 1 June 2017
Periodontal tissue regeneration is the ultimate goal of the treatment for periodontitis-affected teeth. The success of regenerative modalities relies heavily on the utilization of appropriate biomaterials with specific properties. Poly (lactic-co-glycolic acid) (PLGA), a synthetic aliphatic polyester, has been actively investigated for periodontal therapy due to its favorable mechanical properties, tunable degradation rates, and high biocompatibility. Despite the attractive characteristics, certain constraints associated with PLGA, in terms of its hydrophobicity and limited bioactivity, have led to the introduction of modification strategies that aimed to improve the biological performance of the polymer. Here, we summarize the features of the polymer and update views on progress of its applications as barrier membranes, bone grafts, and drug delivery carriers, which indicate that PLGA can be a good candidate material in the field of periodontal regenerative medicine. View Full-Text
Keywords: poly (lactic-co-glycolic acid); barrier membranes; bone grafts; drug delivery carriers; periodontal tissue regeneration poly (lactic-co-glycolic acid); barrier membranes; bone grafts; drug delivery carriers; periodontal tissue regeneration
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Sun, X.; Xu, C.; Wu, G.; Ye, Q.; Wang, C. Poly(Lactic-co-Glycolic Acid): Applications and Future Prospects for Periodontal Tissue Regeneration. Polymers 2017, 9, 189.

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