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Open AccessArticle

Novel Wet Micro-Contact Deprinting Method for Patterning Gold Nanoparticles on PEG-Hydrogels and Thereby Controlling Cell Adhesion

Technische Universität Berlin, Nanopatterned Biomaterials, Sekr. TC 1, Strasse des 17. Juni 124, 10623 Berlin, Germany
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Academic Editor: Helmut Schlaad
Polymers 2017, 9(5), 176; https://doi.org/10.3390/polym9050176
Received: 4 April 2017 / Revised: 8 May 2017 / Accepted: 11 May 2017 / Published: 15 May 2017
(This article belongs to the Special Issue Bio-inspired and Bio-based Polymers)
In the present work we introduce a novel method to create linear and rectangular micro-patterns of gold nanoparticles (Au NPs) on poly(ethylene glycol) (PEG) hydrogels. The strategy consists of removing Au NPs from defined regions of the silicon wafer by virtue of the swelling effect of the hydrogel. Using this method, which we denote as “Wet Micro-Contact Deprinting”, well-defined micro-patterns of Au NPs on silicon can be created. This resulting pattern is then transferred from the hard substrate to the soft surface of PEG-hydrogels. These unique micro- and nano-patterned hydrogels were cultured with mouse fibroblasts L929 cells. The cells selectively adhered on the Au NPs coated area and avoided the pure PEG material. These patterned, nanocomposite biointerfaces are not only useful for biological and biomedical applications, such as tissue engineering and diagnostics, but also, for biosensor applications taking advantage of surface plasmon resonance (SPR) or surface enhanced Raman scattering (SERS) effects, due to the optical properties of the Au NPs. View Full-Text
Keywords: gold nanoparticles; poly(ethylene glycol) hydrogel; micro-patterning; swelling; deprinting; cell adhesion gold nanoparticles; poly(ethylene glycol) hydrogel; micro-patterning; swelling; deprinting; cell adhesion
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MDPI and ACS Style

Yesildag, C.; Bartsch, C.; De Vicente, G.; Lensen, M.C. Novel Wet Micro-Contact Deprinting Method for Patterning Gold Nanoparticles on PEG-Hydrogels and Thereby Controlling Cell Adhesion. Polymers 2017, 9, 176.

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