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Open AccessReview

Stimuli-Regulated Smart Polymeric Systems for Gene Therapy

Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, Korea
Department of Plastic Surgery, Institute of Dermatology and Plastic Surgery, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Ravin Narain
Polymers 2017, 9(4), 152;
Received: 5 April 2017 / Revised: 19 April 2017 / Accepted: 20 April 2017 / Published: 24 April 2017
(This article belongs to the Special Issue Polymers and Nanogels for Gene Therapy)
The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers. View Full-Text
Keywords: stimuli-responsive system; internal stimuli; transfection; gene carrier; enzyme; temperature; polyplexes stimuli-responsive system; internal stimuli; transfection; gene carrier; enzyme; temperature; polyplexes
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MDPI and ACS Style

Mathew, A.P.; Cho, K.-H.; Uthaman, S.; Cho, C.-S.; Park, I.-K. Stimuli-Regulated Smart Polymeric Systems for Gene Therapy. Polymers 2017, 9, 152.

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