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Polymers 2017, 9(11), 555;

Effect of Perfluoroalkyl Endgroups on the Interactions of Tri-Block Copolymers with Monofluorinated F-DPPC Monolayers

Institute of Chemistry, Martin-Luther University Halle-Wittenberg, D 06099 Halle, Germany
Chemistry Department, Hazara University, 21120 Mansehra, Pakistan
Author to whom correspondence should be addressed.
Received: 28 September 2017 / Revised: 20 October 2017 / Accepted: 21 October 2017 / Published: 25 October 2017
(This article belongs to the Special Issue From Amphiphilic to Polyphilic Polymers)
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We studied the interaction of amphiphilic and triphilic polymers with monolayers prepared from F-DPPC (1-palmitoyl-2-(16-fluoropalmitoyl)-sn-glycero-3-phosphocholine), a phospholipid with a single fluorine atom at the terminus of the sn-2 chain, an analogue of dipalmitoyl-phosphatidylcholine (DPPC). The amphiphilic block copolymers contained a hydrophobic poly(propylene oxide) block flanked by hydrophilic poly(glycerol monomethacrylate) blocks (GP). F-GP was derived from GP by capping both termini with perfluoro-n-nonyl segments. We first studied the adsorption of GP and F-GP to lipid monolayers of F-DPPC. F-GP was inserted into the monolayer up to a surface pressure Π of 42.4 mN m−1, much higher than GP (32.5 mN m−1). We then studied isotherms of lipid-polymer mixtures co-spread at the air-water interface. With increasing polymer content in the mixture a continuous shift of the onset of the liquid-expanded (LE) to liquid-condensed (LC) transition towards higher molecular and higher area per lipid molecule was observed. F-GP had a larger effect than GP indicating that it needed more space. At a Π-value of 32 mN m−1, GP was excluded from the mixed monolayer, whereas F-GP stayed in F-DPPC monolayers up to 42 mN m−1. F-GP is thus more stably anchored in the monolayer up to higher surface pressures. Images of mixed monolayers were acquired using different fluorescent probes and showed the presence of perfluorinated segments of F-GP at LE-LC domain boundaries. View Full-Text
Keywords: F-DPPC; polyphilic block copolymers; amphiphilic block copolymers; lipid monolayers F-DPPC; polyphilic block copolymers; amphiphilic block copolymers; lipid monolayers

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Shah, S.W.H.; Schwieger, C.; Li, Z.; Kressler, J.; Blume, A. Effect of Perfluoroalkyl Endgroups on the Interactions of Tri-Block Copolymers with Monofluorinated F-DPPC Monolayers. Polymers 2017, 9, 555.

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