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Polymers 2017, 9(10), 469;

Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction

Shanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China
Authors to whom correspondence should be addressed.
Received: 31 August 2017 / Revised: 20 September 2017 / Accepted: 21 September 2017 / Published: 24 September 2017
(This article belongs to the Special Issue Polymers and Block Copolymers at Interfaces and Surfaces)
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To fabricate molecularly imprinted polymer nanospheres via click reaction, five different clickable compounds were synthesized and two types of click reactions (azide-alkyne and thiol-yne) were explored. It was found that molecularly imprinted polymer nanospheres could be successfully synthesized via thiol-yne click reaction using 3,5-diethynyl-pyridine (1) as the monomer, tris(3-mercaptopropionate) (tri-thiol, 5) as the crosslinker, and hypericin as the template (MIP–NSHs). The click polymerization completed in merely 4 h to produce the desired MIP–NSHs, which were characterized by FTIR, SEM, DLS, and BET, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the MIP–NSHs synthesized under the optimized conditions showed a high adsorption capacity (Q = 6.03 μmol•g−1) towards hypericin. The imprinting factors of MIP–NSHs towards hypericin, protohypericin, and emodin were 2.44, 2.88, and 2.10, respectively. View Full-Text
Keywords: molecular imprinting; hypericin; click reaction; nanospheres molecular imprinting; hypericin; click reaction; nanospheres

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pei, Y.; Fan, F.; Wang, X.; Feng, W.; Hou, Y.; Pei, Z. Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction. Polymers 2017, 9, 469.

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