Polymers 2015, 7(7), 1269-1278; https://doi.org/10.3390/polym7071269
pH-Dependent Release of Insulin from Layer-by-Layer-Deposited Polyelectrolyte Microcapsules
Kentaro Yoshida 1,*
, Tetsuya Ono 1, Yoshitomo Kashiwagi 1, Shigehiro Takahashi 2, Katsuhiko Sato 2 and Jun-ichi Anzai 2
1
School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
2
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Cyrille Boyer
Received: 7 May 2015 / Revised: 24 June 2015 / Accepted: 3 July 2015 / Published: 13 July 2015
(This article belongs to the Special Issue Polymers and Polymeric Nanoparticles for Therapy and Imaging)
Abstract
Insulin-containing microcapsules were prepared by a layer-by-layer (LbL) deposition of poly(allylamine hydrochloride) (PAH) and polyanions, such as poly(styrenesulfonate) (PSS), poly(vinyl sulfate) (PVS), and dextran sulfate (DS) on insulin-containing calcium carbonate (CaCO3) microparticles. The CaCO3 core was dissolved in diluted HCl solution to obtain insulin-containing hollow microcapsules. The microcapsules were characterized by scanning electron microscope (SEM) and atomic force microscope (AFM) images and ζ-potential. The release of insulin from the microcapsules was faster at pH 9.0 and 7.4 than in acidic solutions due to the different charge density of PAH. In addition, insulin release was suppressed when the microcapsules were constructed using PAH with a lower molecular weight, probably owing to a thicker shell of the microcapsules. The results suggested a potential use of the insulin-containing microcapsules for developing insulin delivery systems. View Full-TextKeywords:
insulin; controlled release; polyelectrolyte microcapsule; layer-by-layer film; drug delivery
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Yoshida, K.; Ono, T.; Kashiwagi, Y.; Takahashi, S.; Sato, K.; Anzai, J.-I. pH-Dependent Release of Insulin from Layer-by-Layer-Deposited Polyelectrolyte Microcapsules. Polymers 2015, 7, 1269-1278.
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