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Article
Peer-Review Record

Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells

Polymers 2022, 14(9), 1882; https://doi.org/10.3390/polym14091882
by Zhiyuan Zhao 1,2,3,†, Tong Wu 2,3,†, Yu Cui 2,3, Rui Zhao 1,2,3, Qi Wan 2,3,* and Rui Xu 1,3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Polymers 2022, 14(9), 1882; https://doi.org/10.3390/polym14091882
Submission received: 11 February 2022 / Revised: 13 April 2022 / Accepted: 25 April 2022 / Published: 5 May 2022
(This article belongs to the Special Issue Advanced Polymers for Biomedical Applications)

Round 1

Reviewer 1 Report

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Author Response

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Reviewer 2 Report

In this manuscript, PLGA, TMP, and chitosan were used to prepare a nanofibrous dura mater that can play a neuroprotective role to prevent the formation of dura adhesion and scar tissue. The present form of the manuscript would be acceptable for publication after minor revision:

  1. The mechanical performance of the fabricated nanofibrous dura mater is relevant to report. In fact, the biological activities of cells are significantly influenced by the biomechanical features of an implant. We suggest investigating the effect of chitosan on the elasticity \stiffness of the fibers. 
  2. DSC, TGA, and DMTA could be performed to determine the effects of TMP and chitosan on the mechanical and physicochemical features of the PLGA. 

Author Response

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Round 2

Reviewer 1 Report

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Author Response

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