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Open AccessArticle

Curdlan–Chitosan Electrospun Fibers as Potential Scaffolds for Bone Regeneration

1
CRCINA, SFR ICAT, University Angers, Université de Nantes, Inserm, F-49000 Angers, France
2
Center for Education and Research on Macromolecules (CERM), CESAM-UR, University of Liège, B-4000 Liège, Belgium
3
Université de Nantes, CNRS, Institut des Matériaux Jean Rouxel, IMN, F-44000 Nantes, France
4
INSERM, UMR 1229, RMeS, Regenerative Medicine and Skeleton, ONIRIS, Université de Nantes, F-44042 Nantes, France
5
UFR Odontologie, Université de Nantes, F-44042 Nantes, France
6
CHU Nantes, PHU4 OTONN, F-44093 Nantes, France
7
School of Pharmacy, University of the Western Cape, Bellville 7535, South Africa
*
Authors to whom correspondence should be addressed.
Academic Editor: Fedor S. Senatov
Polymers 2021, 13(4), 526; https://doi.org/10.3390/polym13040526
Received: 27 January 2021 / Revised: 5 February 2021 / Accepted: 5 February 2021 / Published: 10 February 2021
(This article belongs to the Special Issue Applications of Biopolymer Scaffolds)
Polysaccharides have received a lot of attention in biomedical research for their high potential as scaffolds owing to their unique biological properties. Fibrillar scaffolds made of chitosan demonstrated high promise in tissue engineering, especially for skin. As far as bone regeneration is concerned, curdlan (1,3-β-glucan) is particularly interesting as it enhances bone growth by helping mesenchymal stem cell adhesion, by favoring their differentiation into osteoblasts and by limiting the osteoclastic activity. Therefore, we aim to combine both chitosan and curdlan polysaccharides in a new scaffold for bone regeneration. For that purpose, curdlan was electrospun as a blend with chitosan into a fibrillar scaffold. We show that this novel scaffold is biodegradable (8% at two weeks), exhibits a good swelling behavior (350%) and is non-cytotoxic in vitro. In addition, the benefit of incorporating curdlan in the scaffold was demonstrated in a scratch assay that evidences the ability of curdlan to express its immunomodulatory properties by enhancing cell migration. Thus, these innovative electrospun curdlan–chitosan scaffolds show great potential for bone tissue engineering. View Full-Text
Keywords: curdlan; chitosan; electrospinning; regenerative medicine; tissue engineering curdlan; chitosan; electrospinning; regenerative medicine; tissue engineering
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MDPI and ACS Style

Toullec, C.; Le Bideau, J.; Geoffroy, V.; Halgand, B.; Buchtova, N.; Molina-Peña, R.; Garcion, E.; Avril, S.; Sindji, L.; Dube, A.; Boury, F.; Jérôme, C. Curdlan–Chitosan Electrospun Fibers as Potential Scaffolds for Bone Regeneration. Polymers 2021, 13, 526. https://doi.org/10.3390/polym13040526

AMA Style

Toullec C, Le Bideau J, Geoffroy V, Halgand B, Buchtova N, Molina-Peña R, Garcion E, Avril S, Sindji L, Dube A, Boury F, Jérôme C. Curdlan–Chitosan Electrospun Fibers as Potential Scaffolds for Bone Regeneration. Polymers. 2021; 13(4):526. https://doi.org/10.3390/polym13040526

Chicago/Turabian Style

Toullec, Clément; Le Bideau, Jean; Geoffroy, Valerie; Halgand, Boris; Buchtova, Nela; Molina-Peña, Rodolfo; Garcion, Emmanuel; Avril, Sylvie; Sindji, Laurence; Dube, Admire; Boury, Frank; Jérôme, Christine. 2021. "Curdlan–Chitosan Electrospun Fibers as Potential Scaffolds for Bone Regeneration" Polymers 13, no. 4: 526. https://doi.org/10.3390/polym13040526

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