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Article

Effect of Molecular Weight and Nanoarchitecture of Chitosan and Polycaprolactone Electrospun Membranes on Physicochemical and Hemocompatible Properties for Possible Wound Dressing

1
Grupo de Dinámica Cardiovascular, Centro de Bioingeniería, Universidad Pontificia Bolivariana, Medellín 050031, Colombia
2
Laboratorio de Síntesis and Modificación de Nanoestructuras and Materiales Bidimensionales, Centro de Investigación en Materiales Avanzados, Chihuahua 31136, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Lilia Sabantina, Ramiro Rafael Ruiz Rosas, Juana María Rosas and Francisco José García-Mateos
Polymers 2021, 13(24), 4320; https://doi.org/10.3390/polym13244320
Received: 9 November 2021 / Revised: 29 November 2021 / Accepted: 3 December 2021 / Published: 10 December 2021
(This article belongs to the Special Issue Polymeric Nanofibers and Nanotextiles for High-Tech Applications)
Tissue engineering has focused on the development of biomaterials that emulate the native extracellular matrix. Therefore, the purpose of this research was oriented to the development of nanofibrillar bilayer membranes composed of polycaprolactone with low and medium molecular weight chitosan, evaluating their physicochemical and biological properties. Two-bilayer membranes were developed by an electrospinning technique considering the effect of chitosan molecular weight and parameter changes in the technique. Subsequently, the membranes were evaluated by scanning electron microscopy, Fourier transform spectroscopy, stress tests, permeability, contact angle, hemolysis evaluation, and an MTT test. From the results, it was found that changes in the electrospinning parameters and the molecular weight of chitosan influence the formation, fiber orientation, and nanoarchitecture of the membranes. Likewise, it was evidenced that a higher molecular weight of chitosan in the bilayer membranes increases the stiffness and favors polar anchor points. This increased Young’s modulus, wettability, and permeability, which, in turn, influenced the reduction in the percentage of cell viability and hemolysis. It is concluded that the development of biomimetic bilayer nanofibrillar membranes modulate the physicochemical properties and improve the hemolytic behavior so they can be used as a hemocompatible biomaterial. View Full-Text
Keywords: nanoarchitecture; bilayer membrane; electrospinning; chitosan; hemocompatibility nanoarchitecture; bilayer membrane; electrospinning; chitosan; hemocompatibility
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MDPI and ACS Style

Oviedo, M.; Montoya, Y.; Agudelo, W.; García-García, A.; Bustamante, J. Effect of Molecular Weight and Nanoarchitecture of Chitosan and Polycaprolactone Electrospun Membranes on Physicochemical and Hemocompatible Properties for Possible Wound Dressing. Polymers 2021, 13, 4320. https://doi.org/10.3390/polym13244320

AMA Style

Oviedo M, Montoya Y, Agudelo W, García-García A, Bustamante J. Effect of Molecular Weight and Nanoarchitecture of Chitosan and Polycaprolactone Electrospun Membranes on Physicochemical and Hemocompatible Properties for Possible Wound Dressing. Polymers. 2021; 13(24):4320. https://doi.org/10.3390/polym13244320

Chicago/Turabian Style

Oviedo, Maria, Yuliet Montoya, Wilson Agudelo, Alejandra García-García, and John Bustamante. 2021. "Effect of Molecular Weight and Nanoarchitecture of Chitosan and Polycaprolactone Electrospun Membranes on Physicochemical and Hemocompatible Properties for Possible Wound Dressing" Polymers 13, no. 24: 4320. https://doi.org/10.3390/polym13244320

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