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Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

Department of Biotechnology, University of Engineering & Management, Kolkata 700160, India
Department of Food Technology and Bio-Chemical Engineering, Jadavpur University, Kolkata 700032, India
Malda Polytechnic, West Bengal State Council of Technical Education, Government of West Bengal, Malda 732102, India
AMH Energy Pvt. Ltd., Kolkata 700039, India
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata 741249, India
Department of Microbiology, School of Science, RK. University, Rajkot 360020, India
Department of Biotechnology and Bioinformatics, Sambalpur University, Odishsa 768001, India
School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan 16150, Malaysia
Faculty of Agro Based Industry, Universiti Malaysia Kelantan, Kota Bharu 17600, Malaysia
Centre of Excellence, Khallikote University, Berhampur 761008, India
SIAN Institute, Association for Biodiversity Conservation and Research (ABC), Odisha 756001, India
Authors to whom correspondence should be addressed.
Marked authors contributed equally.
Academic Editor: Marzia Marciello
Polymers 2021, 13(15), 2533;
Received: 9 July 2021 / Revised: 23 July 2021 / Accepted: 25 July 2021 / Published: 30 July 2021
(This article belongs to the Special Issue Multifunctional Nanoparticles for Biomedical Applications)
The biggest challenge in the present-day healthcare scenario is the rapid emergence and spread of antimicrobial resistance due to the rampant use of antibiotics in daily therapeutics. Such drug resistance is associated with the enhancement of microbial virulence and the acquisition of the ability to evade the host’s immune response under the shelter of a biofilm. Quorum sensing (QS) is the mechanism by which the microbial colonies in a biofilm modulate and intercept communication without direct interaction. Hence, the eradication of biofilms through hindering this communication will lead to the successful management of drug resistance and may be a novel target for antimicrobial chemotherapy. Chitosan shows microbicidal activities by acting electrostatically with its positively charged amino groups, which interact with anionic moieties on microbial species, causing enhanced membrane permeability and eventual cell death. Therefore, nanoparticles (NPs) prepared with chitosan possess a positive surface charge and mucoadhesive properties that can adhere to microbial mucus membranes and release their drug load in a constant release manner. As the success in therapeutics depends on the targeted delivery of drugs, chitosan nanomaterial, which displays low toxicity, can be safely used for eradicating a biofilm through attenuating the quorum sensing (QS). Since the anti-biofilm potential of chitosan and its nano-derivatives are reported for various microorganisms, these can be used as attractive tools for combating chronic infections and for the preparation of functionalized nanomaterials for different medical devices, such as orthodontic appliances. This mini-review focuses on the mechanism of the downregulation of quorum sensing using functionalized chitosan nanomaterials and the future prospects of its applications. View Full-Text
Keywords: antibiofilm; chitosan; nanomaterial; quorum quenching; quorum sensing antibiofilm; chitosan; nanomaterial; quorum quenching; quorum sensing
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MDPI and ACS Style

Nag, M.; Lahiri, D.; Mukherjee, D.; Banerjee, R.; Garai, S.; Sarkar, T.; Ghosh, S.; Dey, A.; Ghosh, S.; Pattnaik, S.; Edinur, H.A.; Kari, Z.A.; Pati, S.; Ray, R.R. Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing. Polymers 2021, 13, 2533.

AMA Style

Nag M, Lahiri D, Mukherjee D, Banerjee R, Garai S, Sarkar T, Ghosh S, Dey A, Ghosh S, Pattnaik S, Edinur HA, Kari ZA, Pati S, Ray RR. Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing. Polymers. 2021; 13(15):2533.

Chicago/Turabian Style

Nag, Moupriya, Dibyajit Lahiri, Dipro Mukherjee, Ritwik Banerjee, Sayantani Garai, Tanmay Sarkar, Sujay Ghosh, Ankita Dey, Sougata Ghosh, Smaranika Pattnaik, Hisham Atan Edinur, Zulhisyam Abdul Kari, Siddhartha Pati, and Rina Rani Ray. 2021. "Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing" Polymers 13, no. 15: 2533.

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