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Article

Formation of Uni-Lamellar Vesicles in Mixtures of DPPC with PEO-b-PCL Amphiphilic Diblock Copolymers

1
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
2
Department of Pharmaceutical Technology, Faculty of Pharmacy, Panepistimioupolis Zografou, National and Kapodistrian University of Athens, 15771 Athens, Greece
3
Jülich Centre for Neutron Science JCNS, Forschungszentrum Jülich GmbH, Outstation at Heinz Maier-Leibnitz Zentrum (MLZ), Lichtenbergstraße 1, 85747 Garching, Germany
*
Author to whom correspondence should be addressed.
Polymers 2021, 13(1), 4; https://doi.org/10.3390/polym13010004
Received: 7 December 2020 / Revised: 18 December 2020 / Accepted: 18 December 2020 / Published: 22 December 2020
(This article belongs to the Special Issue Polymers in Pharmaceutical Technology)
The ability of mixtures of 1.2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and the amphiphilic diblock copolymers poly (ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) to stabilize uni-lamellar nano-vesicles is reported. Small angle neutron scattering (SANS) is used to define their size distribution and bilayer structure and resolve the copresence of aggregates and clusters in solution. The vesicles have a broad size distribution which is compatible with bilayer membranes of relatively low bending stiffness. Their mean diameter increases moderately with temperature and their number density and mass is higher in the case of the diblock copolymer with the larger hydrophobic block. Bayesian analysis is performed in order to justify the use of the particular SANS fitting model and confirm the reliability of the extracted parameters. This study shows that amphiphilic block copolymers can be effectively used to prepare mixed lipid-block copolymer vesicles with controlled lamellarity and a significant potential as nanocarriers for drug delivery. View Full-Text
Keywords: liposomes; vesicles; small angle neutron scattering; Bayesian analysis; block copolymers liposomes; vesicles; small angle neutron scattering; Bayesian analysis; block copolymers
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MDPI and ACS Style

Papagiannopoulos, A.; Pippa, N.; Demetzos, C.; Pispas, S.; Radulescu, A. Formation of Uni-Lamellar Vesicles in Mixtures of DPPC with PEO-b-PCL Amphiphilic Diblock Copolymers. Polymers 2021, 13, 4. https://doi.org/10.3390/polym13010004

AMA Style

Papagiannopoulos A, Pippa N, Demetzos C, Pispas S, Radulescu A. Formation of Uni-Lamellar Vesicles in Mixtures of DPPC with PEO-b-PCL Amphiphilic Diblock Copolymers. Polymers. 2021; 13(1):4. https://doi.org/10.3390/polym13010004

Chicago/Turabian Style

Papagiannopoulos, Aristeidis, Natassa Pippa, Costas Demetzos, Stergios Pispas, and Aurel Radulescu. 2021. "Formation of Uni-Lamellar Vesicles in Mixtures of DPPC with PEO-b-PCL Amphiphilic Diblock Copolymers" Polymers 13, no. 1: 4. https://doi.org/10.3390/polym13010004

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