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Open AccessArticle

Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins

1
Laboratory of Interfaces and Nanostructures, Institute of Chemistry, Eötvös Loránd University, Budapest 112, PO Box 32, H-1518 Budapest, Hungary
2
Biological Nanochemistry Research Group, Institute of Materials and EnvironmentalChemistry, Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary
3
NMR Research Laboratory, Instrumentation Center, Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary
4
CycloLab Cyclodextrin Research and Development Laboratory Ltd., Illatos út 7, H-1097 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(9), 2167; https://doi.org/10.3390/polym12092167
Received: 18 August 2020 / Revised: 12 September 2020 / Accepted: 16 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Polymers and Drug Delivery Systems)
The limited bioavailability of the highly hydrophobic natural compound, curcumin with wide range of beneficial bioactivity is still a challenge. Self-association type systems of polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymers (Pluronic) were applied to enhance the aqueous solubility of curcumin. Comparison of four Pluronics (94, 105, 127,108) with different compositions led to the conclusion that solubilization capacity is maximum for Pluronic 105 with intermediate polarity (hydrophilic/lipophilic balance (HLB) = 15) possessing the optimum balance between capacity of hydrophobic core of the micelle and hydrophilic stabilizing shell of the associate. Curcumin concentration in aqueous solution was managed to increase 105 times up to 1–3 g/L applying Pluronic at 0.01 mol/L. Formation of a host–guest complex of cyclodextrin as another way of increasing the curcumin solubility was also tested. Comparing the(2-hydroxypropyl)-α, β and γ cyclodextrins (CD) with 6, 7 and 8 sugar units and their polymers (poly-α-CD, poly-β-CD, poly-γ-CD) the γ-CD with the largest cavity found to be the most effective in curcumin encapsulation approaching the g/L range of concentration. The polymer type of the CDs presented prolonged and pH dependent release of curcumin in the gastrointestinal (GI) system modelled by simulated liquids. This retarding effect of polyCD was also shown and can be used for tuning in the combined system of Pluronic micelle and polyCD where the curcumin release was slower than from the micelle. View Full-Text
Keywords: curcumin solubilization; Pluronic micelle; cyclodextrin and polymeric cyclodextrin; release of curcumin from drug delivery system curcumin solubilization; Pluronic micelle; cyclodextrin and polymeric cyclodextrin; release of curcumin from drug delivery system
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MDPI and ACS Style

Nagy, N.Z.; Varga, Z.; Mihály, J.; Domján, A.; Fenyvesi, É.; Kiss, É. Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins. Polymers 2020, 12, 2167.

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