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Open AccessArticle

Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

1
“Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41 A Gr. Ghica Voda Alley, 700487 Iasi, Romania
2
Department of Biomedical Sciences, Faculty of Medical Bioengineering, “Grigore T. Popa” University of Medicine and Pharmacy, 9-13 M. Kogalniceanu Street, 700454 Iasi, Romania
3
Department of Morpho-Functional Sciences, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania
4
Department of Textiles and Leather Chemical Engineering, “Gheorghe Asachi” Technical University of Iasi, 700050 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(7), 1473; https://doi.org/10.3390/polym12071473
Received: 18 May 2020 / Revised: 26 June 2020 / Accepted: 26 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Functional Chitosan-Based Composites)
The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.
Keywords: superabsorbent hydrogel; N-citraconyl-chitosan; poly(acrylic acid)/poly(methacrylic acid) superabsorbent hydrogel; N-citraconyl-chitosan; poly(acrylic acid)/poly(methacrylic acid)
MDPI and ACS Style

Duceac, I.A.; Verestiuc, L.; Dimitriu, C.D.; Maier, V.; Coseri, S. Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications. Polymers 2020, 12, 1473.

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