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Article

Chemoenzymatic Synthesis of D-Glucitol-Based Non-Ionic Amphiphilic Architectures as Nanocarriers

1
Department of Chemistry, University of Delhi, Delhi-110 007, India
2
Institut für Chemie und Biochemie, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany
3
Forschungszentrum für Elektronenmikroskopie, Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstraße 36a, 14195 Berlin, Germany
4
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(6), 1421; https://doi.org/10.3390/polym12061421
Received: 31 May 2020 / Revised: 19 June 2020 / Accepted: 23 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue Enzymatic Synthesis of Polymers)
Newer non-ionic amphiphiles have been synthesized using biocompatible materials and by following a greener approach i.e., D-glucitol has been used as a template, and hydrophobic and hydrophilic segments were incorporated on it by using click chemistry. The hydrophilic segments in turn were prepared from glycerol using an immobilized Candida antarctica lipase (Novozym-435)-mediated chemoenzymatic approach. Surface tension measurements and dynamic light scattering studies reflect the self-assembling behavior of the synthesized amphiphilic architectures in the aqueous medium. The results from UV-Vis and fluorescence spectroscopy establish the encapsulation of guests in the hydrophobic core of self-assembled amphiphilic architectures. The results of 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay indicate that the amphiphiles are well tolerated by the used A549 cell lines at all tested concentrations. View Full-Text
Keywords: D-Glucitol; Candida antarctica lipase; non-ionic amphiphiles; click chemistry; cyto-compatible; nanocarrier D-Glucitol; Candida antarctica lipase; non-ionic amphiphiles; click chemistry; cyto-compatible; nanocarrier
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MDPI and ACS Style

Manchanda, P.; Achazi, K.; Verma, D.; Böttcher, C.; Haag, R.; Sharma, S.K. Chemoenzymatic Synthesis of D-Glucitol-Based Non-Ionic Amphiphilic Architectures as Nanocarriers. Polymers 2020, 12, 1421. https://doi.org/10.3390/polym12061421

AMA Style

Manchanda P, Achazi K, Verma D, Böttcher C, Haag R, Sharma SK. Chemoenzymatic Synthesis of D-Glucitol-Based Non-Ionic Amphiphilic Architectures as Nanocarriers. Polymers. 2020; 12(6):1421. https://doi.org/10.3390/polym12061421

Chicago/Turabian Style

Manchanda, Priyanka, Katharina Achazi, Diksha Verma, Christoph Böttcher, Rainer Haag, and Sunil K. Sharma 2020. "Chemoenzymatic Synthesis of D-Glucitol-Based Non-Ionic Amphiphilic Architectures as Nanocarriers" Polymers 12, no. 6: 1421. https://doi.org/10.3390/polym12061421

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