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Article

Development and Evaluation of a Polyvinylalcohol -Cellulose Derivative-Based Film with Povidone-Iodine Predicted for Wound Treatment

1
Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland
2
Department of Analytical Chemistry, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland
3
Department of Periodontology, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
4
Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland
5
Department of Animal Physiology and Biostructure, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(6), 1271; https://doi.org/10.3390/polym12061271
Received: 28 April 2020 / Revised: 28 May 2020 / Accepted: 29 May 2020 / Published: 2 June 2020
(This article belongs to the Special Issue Polymers for Pharmaceutical Applications)
The aim of this study was to develop and assess a polyvinyl alcohol-cellulose derivatives-based film with incorporated povidone-iodine (PVP-I) predicted for applications in the treatment of periodontitis. Films were fabricated by solvent-casting, and their physical characteristics, such as their surface and structure morphology, mechanical properties, and disintegrating time, were evaluated. For in vitro iodine release studies and evaluation, the antimicrobial activity was tested using a modified disc diffusion method against five microbial strains. For further use, we selected the film with polyvinyl alcohol-hydroxypropyl methylcellulose (PVA/HPMC_B) based on acceptable physicochemical properties. To assess the subacute toxicity of the film composition, the tissue regeneration process was tested in rats and compared to a conventional dressing commonly used in wound healing (Spongostan). Seven days after implantation, dorsal skin sections and blood samples (n = 10, in total n = 30) were examined. The wound area, epithelium, and dermis were evaluated microscopically, while the blood collected from the rats underwent biochemical analysis. The blood biochemistry results were comparable in all three groups. No significant histological differences between the Spongostan and the placebo film developed after subcutaneous implantation were observed. In contrast, the inflammation stage was reduced and the “scar” in the dermis was smaller when PVP-I and PVA/HPMC_B films were used. A smaller local inflammatory response inflicted less tissue damage, leading to the activation of subsequent regeneration phases and restoration of the area to its original state. The results obtained confirmed that PVP-I incorporated into PVA-hydroxypropyl methylcellulose film is a promising drug carrier, working faster and more effectively than the other two dressing materials evaluated. These developments provide a promising alternative in tissue regeneration and the wound healing process. View Full-Text
Keywords: povidone-iodine; polymer film; cellulose derivatives; polyvinyl alcohol; rat model; tissue regeneration povidone-iodine; polymer film; cellulose derivatives; polyvinyl alcohol; rat model; tissue regeneration
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MDPI and ACS Style

Kida, D.; Gładysz, O.; Szulc, M.; Zborowski, J.; Junka, A.; Janeczek, M.; Lipińska, A.; Skalec, A.; Karolewicz, B. Development and Evaluation of a Polyvinylalcohol -Cellulose Derivative-Based Film with Povidone-Iodine Predicted for Wound Treatment. Polymers 2020, 12, 1271. https://doi.org/10.3390/polym12061271

AMA Style

Kida D, Gładysz O, Szulc M, Zborowski J, Junka A, Janeczek M, Lipińska A, Skalec A, Karolewicz B. Development and Evaluation of a Polyvinylalcohol -Cellulose Derivative-Based Film with Povidone-Iodine Predicted for Wound Treatment. Polymers. 2020; 12(6):1271. https://doi.org/10.3390/polym12061271

Chicago/Turabian Style

Kida, Dorota; Gładysz, Olimpia; Szulc, Małgorzata; Zborowski, Jacek; Junka, Adam; Janeczek, Maciej; Lipińska, Anna; Skalec, Aleksandra; Karolewicz, Bożena. 2020. "Development and Evaluation of a Polyvinylalcohol -Cellulose Derivative-Based Film with Povidone-Iodine Predicted for Wound Treatment" Polymers 12, no. 6: 1271. https://doi.org/10.3390/polym12061271

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