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Open AccessArticle

Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

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Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, Magurele, 077190 Ilfov, Romania
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Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060274 Bucharest, Romania
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Laboratory of Optical Processes in Nanostructured Materials, National Institute of Materials Physics, Magurele, 077190 Ilfov, Romania
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Department of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, 060274 Bucharest, Romania
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Proteomics Department, Institute of Cellular Biology and Pathology “N. Simionescu” Romanian Academy, 060274 Bucharest, Romania
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Department of Metallic Materials Science, Physical Metallurgy, Faculty of Materials Science and Engineering, University Politehnica of Bucharest, 060274 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(3), 717; https://doi.org/10.3390/polym12030717
Received: 28 January 2020 / Revised: 4 March 2020 / Accepted: 7 March 2020 / Published: 24 March 2020
(This article belongs to the Special Issue Biopolymers for Biomedical Applications)
Our study focused on the long-term degradation under simulated conditions of coatings based on different compositions of polycaprolactone-polyethylene glycol blends (PCL-blend-PEG), fabricated for titanium implants by a dip-coating technique. The degradation behavior of polymeric coatings was evaluated by polymer mass loss measurements of the PCL-blend-PEG during immersion in SBF up to 16 weeks and correlated with those yielded from electrochemical experiments. The results are thoroughly supported by extensive compositional and surface analyses (FTIR, GIXRD, SEM, and wettability investigations). We found that the degradation behavior of PCL-blend-PEG coatings is governed by the properties of the main polymer constituents: the PEG solubilizes fast, immediately after the immersion, while the PCL degrades slowly over the whole period of time. Furthermore, the results evidence that the alteration of blend coatings is strongly enhanced by the increase in PEG content. The biological assessment unveiled the beneficial influence of PCL-blend-PEG coatings for the adhesion and spreading of both human-derived mesenchymal stem cells and endothelial cells. View Full-Text
Keywords: degradation; electrochemistry; dip-coating; PCL-PEG blends; mass loss degradation; electrochemistry; dip-coating; PCL-PEG blends; mass loss
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MDPI and ACS Style

Visan, A.I.; Popescu-Pelin, G.; Gherasim, O.; Mihailescu, A.; Socol, M.; Zgura, I.; Chiritoiu, M.; Elena Sima, L.; Antohe, F.; Ivan, L.; M. Vranceanu, D.; M. Cotruț, C.; Cristescu, R.; Socol, G. Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions. Polymers 2020, 12, 717.

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