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Open AccessArticle

Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules

1
Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), Russian Federation, V.O. Bolshoy pr. 31, 199004 Saint Petersburg, Russia
2
Federal State Budgetary Institution “Russian Research Center for Radiology and Surgical Technologies” of the Ministry of Health of the Russian Federation, Russian Federation, p. Pesochny, ul. Leningradskaya, 70, 197758 Saint Petersburg, Russia
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(12), 2889; https://doi.org/10.3390/polym12122889
Received: 6 November 2020 / Revised: 23 November 2020 / Accepted: 26 November 2020 / Published: 2 December 2020
(This article belongs to the Section Polymer Chemistry)
Copolymer of N-vinylpyrrolidone (VP) with vinylformamide (VFA) and N-vinyliminodiacetic acid (VIDA) was synthesized; its metal-polymer complexes (MPCs) with gallium were obtained. The complexes were characterized by size exclusion chromatography, hydrodynamic and optical methods, scanning electron microscopy, and spectral methods (UV, IR, 1Н NMR spectroscopy). It was demonstrated that in going from polymer to complex, hydrodynamic parameters of macromolecules change only slightly, although the polymer contains intramolecular Ga(VIDA)2 fragments in its structure. A new method for preparation of MPCs with gallium and gallium-68 radionuclide was suggested. The obtained metal-polymer complex is stable over a wide range of pH values as well as in the histidine challenge reaction. In vivo distribution experiments in intact animals showed high primary accumulation of thegallium-68 MPC in blood with subsequent excretion via urinary tract. View Full-Text
Keywords: water-solublepolymer complexes; N-vinylpyrrolidone; N-vinylamine; iminodiacetic acid; metal-polymer complexes; gallium-68 water-solublepolymer complexes; N-vinylpyrrolidone; N-vinylamine; iminodiacetic acid; metal-polymer complexes; gallium-68
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MDPI and ACS Style

Gorshkov, N.I.; Murko, А.Y..; Gavrilova, I.I.; Bezrukova, М.А.; Kipper, А.I.; Shatik, S.V.; Tokarev, А.V.; Krasikov, V.D.; Panarin, Е.F. Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules. Polymers 2020, 12, 2889. https://doi.org/10.3390/polym12122889

AMA Style

Gorshkov NI, Murko АY, Gavrilova II, Bezrukova МА, Kipper АI, Shatik SV, Tokarev АV, Krasikov VD, Panarin ЕF. Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules. Polymers. 2020; 12(12):2889. https://doi.org/10.3390/polym12122889

Chicago/Turabian Style

Gorshkov, Nikolay I.; Murko, Аndrey Y..; Gavrilova, Iirina I.; Bezrukova, Мarina А.; Kipper, Аlbert I.; Shatik, Sergei V.; Tokarev, Аlexander V.; Krasikov, Valerii D.; Panarin, Еvgenii F. 2020. "Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules" Polymers 12, no. 12: 2889. https://doi.org/10.3390/polym12122889

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