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Open AccessArticle

Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold

1
State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China
2
Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China
3
Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha 410013, China
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(1), 199; https://doi.org/10.3390/polym12010199
Received: 17 December 2019 / Revised: 7 January 2020 / Accepted: 9 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue 3D and 4D Printing of (Bio)Materials)
In order to improve the interfacial bonding between hydroxyapatite (HAP) and poly-l-lactic acid (PLLA), 2-Carboxyethylphosphonic acid (CEPA), a phosphonic acid coupling agent, was introduced to modify HAP nanoparticles. After this. the PLLA scaffold containing CEPA-modified HAP (C-HAP) was fabricated by selective laser sintering (frittage). The specific mechanism of interfacial bonding was that the PO32− of CEPA formed an electrovalent bond with the Ca2+ of HAP on one hand, and on the other hand, the –COOH of CEPA formed an ester bond with the –OH of PLLA via an esterification reaction. The results showed that C-HAP was homogeneously dispersed in the PLLA matrix and that it exhibited interconnected morphology pulled out from the PLLA matrix due to the enhanced interfacial bonding. As a result, the tensile strength and modulus of the scaffold with 20% C-HAP increased by 1.40 and 2.79 times compared to that of the scaffold with HAP, respectively. In addition, the scaffold could attract Ca2+ in simulated body fluid (SBF) solution by the phosphonic acid group to induce apatite layer formation and also release Ca2+ and PO43− by degradation to facilitate cell attachment, growth and proliferation. View Full-Text
Keywords: interfacial bonding; coupling agent; HAP; scaffold interfacial bonding; coupling agent; HAP; scaffold
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MDPI and ACS Style

Shuai, C.; Yu, L.; Yang, W.; Peng, S.; Zhong, Y.; Feng, P. Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold. Polymers 2020, 12, 199.

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