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Open AccessArticle

Gamma-Irradiation-Prepared Low Molecular Weight Hyaluronic Acid Promotes Skin Wound Healing

1
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan
2
Dental Department, En Chu Kong Hospital, New Taipei City 23741, Taiwan
3
Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei 11031, Taiwan
4
Research Center of Biomedical Device, Medical University, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(7), 1214; https://doi.org/10.3390/polym11071214
Received: 4 July 2019 / Revised: 16 July 2019 / Accepted: 17 July 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Medical Application of Polymer-Based Composites)
In this study, we prepared low-molecular-weight hyaluronic acid (LMWHA) powder by γ-irradiation. The chemical and physical properties of γ-irradiated LMWHA and the in vitro cellular growth experiments with γ-irradiated LMWHA were analyzed. Then, hyaluronic acid exposed to 20 kGy of γ-irradiation was used to fabricate a carboxymethyl cellulose (CMC)/LMWHA fabric for wound dressing. Our results showed that γ-irradiated LMWHA demonstrated a significant alteration in carbon–oxygen double bonding and can be detected using nuclear magnetic resonance and ultraviolet (UV)-visible (Vis) spectra. The γ-irradiated LMWHA exhibited strain rate-dependent Newton/non-Newton fluid biphasic viscosity. The viability of L929 skin fibroblasts improved upon co-culture with γ-irradiated LMWHA. In the in vivo animal experiments, skin wounds covered with dressings prepared by γ-irradiation revealed acceleration of wound healing after two days of healing. The results suggest that γ-irradiated LMWHA could be a potential source for the promotion of skin wound healing. View Full-Text
Keywords: low molecular weight; hyaluronic acid; wound healing; gamma ray; membrane low molecular weight; hyaluronic acid; wound healing; gamma ray; membrane
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Huang, Y.-C.; Huang, K.-Y.; Lew, W.-Z.; Fan, K.-H.; Chang, W.-J.; Huang, H.-M. Gamma-Irradiation-Prepared Low Molecular Weight Hyaluronic Acid Promotes Skin Wound Healing. Polymers 2019, 11, 1214.

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