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Open AccessArticle

Synthesis of Novel pH-Tunable Thermoresponsive Hydroxyl-Terminated Hyperbranched Polyether

1
The Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education and Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an 710072, China
2
Department of Pharmceutical analysis of Changzhi Medical College, Changzhi 046000, China
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(5), 895; https://doi.org/10.3390/polym11050895
Received: 9 April 2019 / Revised: 9 May 2019 / Accepted: 14 May 2019 / Published: 16 May 2019
In this study, a new pH-tunable thermoresponsive hydroxyl-terminated hyperbranched polyether (HTHP 2) was successfully prepared via a one-pot cationic polymerization technique and postmodification. In the first step, hydroxyl-terminated hyperbranched polyether containing double bonds (HTHP 1) were synthesized. Then, through thiol-ene “click” reaction, pH-responsive carboxyl groups were introduced to the target polymer of HTHP 2. The products were characterized via Fourier-transform infrared spectra (FTIR), nuclear magnetic resonance (NMR), and size-exclusion chromatography-multiangle laser light scattering (SEC-MALLS). Moreover, dynamic light scattering (DLS) and UV–Vis spectroscopy was employed to study the pH- and thermoresponsiveness in detail. Results showed that HTHP 2 possessed typical pH-controllable thermoresponsive behavior. By regulating the solution pH value range 3.0–5.4, LCST of HTHP 2 could be changed from 12.8 to 68.0 °C. Meanwhile, the cell viabilities of A549 cells were more than 80% for in vitro cytotoxicity tests of HTHP 2, suggested that HTHP 2 polymers are of good biocompatibility for up to 24 h. View Full-Text
Keywords: hydroxyl-terminated hyperbranched polyether; cationic polymerization; thiol-ene “click” reaction; widely tunable LCST hydroxyl-terminated hyperbranched polyether; cationic polymerization; thiol-ene “click” reaction; widely tunable LCST
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MDPI and ACS Style

Zhu, X.; Duan, X.; Bai, T.; Zhang, X.; Wang, T.; Cao, T.; Fan, X. Synthesis of Novel pH-Tunable Thermoresponsive Hydroxyl-Terminated Hyperbranched Polyether. Polymers 2019, 11, 895.

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