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Fe3O4 Nanoparticles Functionalized with Polymer Ligand for T1-Weighted MRI In Vitro and In Vivo

1
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education, Key Laboratory of Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China
2
The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200443, China
3
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
4
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Anhui 230026, China
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(5), 882; https://doi.org/10.3390/polym11050882
Received: 15 January 2019 / Revised: 5 May 2019 / Accepted: 10 May 2019 / Published: 14 May 2019
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Abstract

Magnetic resonance imaging (MRI) has gained wide interest in early accurate diagnoses due to the high resolution and low toxicity of magnetic nanoparticles. In order to develop potential alternatives of toxic Gd- or Mn-based chelating agents, we report the synthesis of water soluble ultra-small Fe3O4 nanoparticles by a modified co-precipitation method as T1-weighted positive contrast agents. The magnetic iron oxide nanoparticles (MIONs) were functionalized by polymer ligand dodecanthiol-polymethacrylic acid (DDT-PMAA) to enhance their colloidal stability. These MIONs have high longitudinal relaxivity (r1 = 8.18 mM−1·S−1) and exhibited good results in the in vitro and in vivo MR imaging. No toxicity was observed in cytotoxicity assay and histology toxicity analysis. The [email protected](magnetic iron oxide nanoparticles @ dodecanthiol-polymethacrylic acid) present great potential as positive contrast agents for tumor diagnosis. View Full-Text
Keywords: MR imaging; Fe3O4 nanoparticles; ultra-small; low toxicity; T1 contrast agents MR imaging; Fe3O4 nanoparticles; ultra-small; low toxicity; T1 contrast agents
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Xiang, C.; Zhong, X.; Yang, W.; Majeed, M.I.; Wang, J.; Yu, J.; Hu, J.; Xu, Z.; Tan, B.; Zhang, B.; Yan, W. Fe3O4 Nanoparticles Functionalized with Polymer Ligand for T1-Weighted MRI In Vitro and In Vivo. Polymers 2019, 11, 882.

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