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Tissue Engineering Strategies for Intervertebral Disc Treatment Using Functional Polymers

1
Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Korea
2
Center for Convergence Bioceramic Materials, Korea Institute of Ceramic Engineering and Technology, Cheongju 28160, Korea
3
Advanced Institutes of Convergence Technology, Gyeonggi-do 16229, Korea
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(5), 872; https://doi.org/10.3390/polym11050872
Received: 3 April 2019 / Revised: 24 April 2019 / Accepted: 2 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Functional Polymers for Biomedicine)
PDF [648 KB, uploaded 13 May 2019]

Abstract

Intervertebral disc (IVD) is the fibrocartilage between the vertebrae, allowing the spine to move steadily by bearing multidirectional complex loads. Aging or injury usually causes degeneration of IVD, which is one of the main reasons for low back pain prevalent worldwide and reduced quality of life. While various treatment strategies for degenerative IVD have been studied using in vitro studies, animal experiments, and clinical trials, there are unsolved limitations for endogenous regeneration of degenerative IVD. In this respect, several tissue engineering strategies that are based on the cell and scaffolds have been extensively researched with positive outcomes for regeneration of IVD tissues. Scaffolds made of functional polymers and their diverse forms mimicking the macro- and micro-structure of native IVD enhance the biological and mechanical properties of the scaffolds for IVD regeneration. In this review, we discuss diverse morphological and functional polymers and tissue engineering strategies for endogenous regeneration of degenerative IVD. Tissue engineering strategies using functional polymers are promising therapeutics for fundamental and endogenous regeneration of degenerative IVD.
Keywords: tissue engineering; functional polymers; intervertebral disc; degenerative disc; regeneration tissue engineering; functional polymers; intervertebral disc; degenerative disc; regeneration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Choi, Y.; Park, M.H.; Lee, K. Tissue Engineering Strategies for Intervertebral Disc Treatment Using Functional Polymers. Polymers 2019, 11, 872.

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