Next Article in Journal
A Strategy of In Situ Catalysis and Nucleation of Biocompatible Zinc Salts of Amino Acids towards Poly(l-lactide) with Enhanced Crystallization Rate
Next Article in Special Issue
Relationship between Degree of Polymeric Ionisation and Hydrolytic Degradation of Eudragit® E Polymers under Extreme Acid Conditions
Previous Article in Journal
In Situ Surface Modification of Paper-Based Relics with Atmospheric Pressure Plasma Treatment for Preservation Purposes
Previous Article in Special Issue
Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate
Open AccessArticle

Butylglyceryl Pectin Nanoparticles: Synthesis, Formulation and Characterization

College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi 112612, UAE
School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael’s Building, Portsmouth PO1 2DT, UK
College of Pharmacy, Al Ain University of Science and Technology, Al Ain 64141, UAE
Author to whom correspondence should be addressed.
Polymers 2019, 11(5), 789;
Received: 28 March 2019 / Revised: 24 April 2019 / Accepted: 26 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Pharmaceutical Polymers)
Pectin is a polysaccharide with very good gel forming properties that traditionally has found important applications in foods and pharmaceutical industries. Although less studied, chemical modifications of pectin leading to a decrease in its hydrophilicity can be useful for the development of novel drug carriers. To this aim, butylglyceryl pectins (P-OX4) were synthesized via functionalization with n-butylglycidyl ether and subsequently formed into nanoparticles. Chromatographic, spectroscopic, and thermal analytical methods were employed to characterize the novel butylglyceryl pectins (P-OX4) obtained, prior to their formulation into nanoparticles via nanoprecipitation. Nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectroscopy confirmed a degree of modification in these materials in the range 10.4–13.6%, and thermal stability studies indicated an increase in both the thermal decomposition onset and glass transition temperature values (compared to those of the original pectin). An increase in the molecular weight and a decrease in the viscosity of P-OX4, when compared to the starting material, were also observed. The resulting nanoformulations were investigated in terms of particle morphology, size and stability, and it was found that particles were roughly spherical, with their size below 300 nm, and a negative zeta potential (−20 to −26 mV, indicating good stability). Having demonstrated the ability to load Doxorubicin at the level of 10%, their potential in drug delivery applications warrants further investigations. View Full-Text
Keywords: polysaccharides; alkylglycerols; N-butylglycidyl ether; pectin; nanoparticles polysaccharides; alkylglycerols; N-butylglycidyl ether; pectin; nanoparticles
Show Figures

Figure 1

MDPI and ACS Style

Bostanudin, M.F.; Arafat, M.; Sarfraz, M.; Górecki, D.C.; Barbu, E. Butylglyceryl Pectin Nanoparticles: Synthesis, Formulation and Characterization. Polymers 2019, 11, 789.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop