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Open AccessArticle

Butylglyceryl Pectin Nanoparticles: Synthesis, Formulation and Characterization

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College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi 112612, UAE
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School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael’s Building, Portsmouth PO1 2DT, UK
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College of Pharmacy, Al Ain University of Science and Technology, Al Ain 64141, UAE
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(5), 789; https://doi.org/10.3390/polym11050789
Received: 28 March 2019 / Revised: 24 April 2019 / Accepted: 26 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Pharmaceutical Polymers)
Pectin is a polysaccharide with very good gel forming properties that traditionally has found important applications in foods and pharmaceutical industries. Although less studied, chemical modifications of pectin leading to a decrease in its hydrophilicity can be useful for the development of novel drug carriers. To this aim, butylglyceryl pectins (P-OX4) were synthesized via functionalization with n-butylglycidyl ether and subsequently formed into nanoparticles. Chromatographic, spectroscopic, and thermal analytical methods were employed to characterize the novel butylglyceryl pectins (P-OX4) obtained, prior to their formulation into nanoparticles via nanoprecipitation. Nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectroscopy confirmed a degree of modification in these materials in the range 10.4–13.6%, and thermal stability studies indicated an increase in both the thermal decomposition onset and glass transition temperature values (compared to those of the original pectin). An increase in the molecular weight and a decrease in the viscosity of P-OX4, when compared to the starting material, were also observed. The resulting nanoformulations were investigated in terms of particle morphology, size and stability, and it was found that particles were roughly spherical, with their size below 300 nm, and a negative zeta potential (−20 to −26 mV, indicating good stability). Having demonstrated the ability to load Doxorubicin at the level of 10%, their potential in drug delivery applications warrants further investigations. View Full-Text
Keywords: polysaccharides; alkylglycerols; N-butylglycidyl ether; pectin; nanoparticles polysaccharides; alkylglycerols; N-butylglycidyl ether; pectin; nanoparticles
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MDPI and ACS Style

Bostanudin, M.F.; Arafat, M.; Sarfraz, M.; Górecki, D.C.; Barbu, E. Butylglyceryl Pectin Nanoparticles: Synthesis, Formulation and Characterization. Polymers 2019, 11, 789.

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