Next Article in Journal
Water/Alcohol Soluble Thickness-Insensitive Hyperbranched Perylene Diimide Electron Transport Layer Improving the Efficiency of Organic Solar Cells
Previous Article in Journal
Thermomechanical Modeling of Amorphous Glassy Polymer Undergoing Large Viscoplastic Deformation: 3-Points Bending and Gas-Blow Forming
Article

Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing

1
CIEPQPF, Department of Chemical Engineering, Universidade de Coimbra, P-3030 790 Coimbra, Portugal
2
CICS-UBI, Health Sciences Research Center, Universidade da Beira Interior, P-6200 506 Covilhã, Portugal
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(4), 653; https://doi.org/10.3390/polym11040653
Received: 4 March 2019 / Revised: 21 March 2019 / Accepted: 8 April 2019 / Published: 10 April 2019
Recently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polycaprolactone and polylactic acid, whereas the underlying layer was comprised of methacrylated gelatin and chitosan. The chemical/physical properties, the in vitro hemo- and biocompatibility of the nanofibrous membranes were evaluated. The results obtained reveal that the produced membranes exhibited a wettability able to provide a moist environment at wound site. Moreover, the membranes’ hemocompatibility and fibroblast cell adhesion, spreading and proliferation at the surface of the membranes were also noticed in the in vitro assays. Such results highlight the suitability of these asymmetric membranes for wound dressing applications. View Full-Text
Keywords: electrospinning; asymmetric membrane; skin regeneration; biocompatibility electrospinning; asymmetric membrane; skin regeneration; biocompatibility
Show Figures

Graphical abstract

MDPI and ACS Style

Alves, P.; Santos, M.; Mendes, S.; P. Miguel, S.; D. de Sá, K.; S. D. Cabral, C.; J. Correia, I.; Ferreira, P. Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing. Polymers 2019, 11, 653. https://doi.org/10.3390/polym11040653

AMA Style

Alves P, Santos M, Mendes S, P. Miguel S, D. de Sá K, S. D. Cabral C, J. Correia I, Ferreira P. Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing. Polymers. 2019; 11(4):653. https://doi.org/10.3390/polym11040653

Chicago/Turabian Style

Alves, Patrícia, Marta Santos, Sabrina Mendes, Sónia P. Miguel, Kevin D. de Sá, Cátia S. D. Cabral, Ilídio J. Correia, and Paula Ferreira. 2019. "Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing" Polymers 11, no. 4: 653. https://doi.org/10.3390/polym11040653

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop