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Review

Recent Advances in Engineered Stem Cell-Derived Cell Sheets for Tissue Regeneration

1
Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea
2
School of Chemical and Biological Engineering, the Institute of Chemical Processes, Seoul National University, Seoul 08826, Korea
3
The BioMax Institute of Seoul National University, Seoul 08826, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2019, 11(2), 209; https://doi.org/10.3390/polym11020209
Received: 15 December 2018 / Revised: 21 January 2019 / Accepted: 23 January 2019 / Published: 26 January 2019
(This article belongs to the Special Issue Functional Polymers for Biomedicine)
The substantial progress made in the field of stem cell-based therapy has shown its significant potential applications for the regeneration of defective tissues and organs. Although previous studies have yielded promising results, several limitations remain and should be overcome for translating stem cell-based therapies to clinics. As a possible solution to current bottlenecks, cell sheet engineering (CSE) is an efficient scaffold-free method for harvesting intact cell sheets without the use of proteolytic enzymes, and may be able to accelerate the adoption of stem cell-based treatments for damaged tissues and organs regeneration. CSE uses a temperature-responsive polymer-immobilized surface to form unique, scaffold-free cell sheets composed of one or more cell layers maintained with important intercellular junctions, cell-secreted extracellular matrices, and other important cell surface proteins, which can be achieved by changing the surrounding temperature. These three-dimensional cell sheet-based tissues can be designed for use in clinical applications to target-specific tissue regeneration. This review will highlight the principles, progress, and clinical relevance of current approaches in the cell sheet-based technology, focusing on stem cell-based therapies for bone, periodontal, skin, and vascularized muscles. View Full-Text
Keywords: cell sheet engineering; smart polymer; temperature-responsiveness; tissue regeneration; stem cell; scaffold-free cell sheet engineering; smart polymer; temperature-responsiveness; tissue regeneration; stem cell; scaffold-free
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MDPI and ACS Style

Kim, H.; Kim, Y.; Park, J.; Hwang, N.S.; Lee, Y.K.; Hwang, Y. Recent Advances in Engineered Stem Cell-Derived Cell Sheets for Tissue Regeneration. Polymers 2019, 11, 209. https://doi.org/10.3390/polym11020209

AMA Style

Kim H, Kim Y, Park J, Hwang NS, Lee YK, Hwang Y. Recent Advances in Engineered Stem Cell-Derived Cell Sheets for Tissue Regeneration. Polymers. 2019; 11(2):209. https://doi.org/10.3390/polym11020209

Chicago/Turabian Style

Kim, Hyunbum, Yunhye Kim, Jihyun Park, Nathaniel S. Hwang, Yun K. Lee, and Yongsung Hwang. 2019. "Recent Advances in Engineered Stem Cell-Derived Cell Sheets for Tissue Regeneration" Polymers 11, no. 2: 209. https://doi.org/10.3390/polym11020209

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