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Article

Calcium Phosphate Incorporated Bacterial Cellulose-Polyvinylpyrrolidone Based Hydrogel Scaffold: Structural Property and Cell Viability Study for Bone Regeneration Application

1
Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic
2
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(11), 1821; https://doi.org/10.3390/polym11111821
Received: 12 September 2019 / Revised: 26 October 2019 / Accepted: 3 November 2019 / Published: 6 November 2019
(This article belongs to the Special Issue Polymers for Bone Tissue Engineering)
This work focuses on the analysis of structural and functional properties of calcium phosphate (CaP) incorporated bacterial cellulose (BC)-polyvinylpyrrolidone (PVP) based hydrogel scaffolds referred to as “CaP/BC-PVP”. CaP is incorporated in the scaffolds in the form of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) in different concentrations (β-TCP: HA (w/w) = 20:80, 40:60, and 50:50). The scaffolds were characterized on the basis of porosity, thermal, biodegradation, mechanical, and cell viability/cytocompatibility properties. The structural properties of all the hydrogel scaffolds show significant porosity. The biodegradation of “CaP/BC-PVP” scaffold was evaluated following hydrolytic degradation. Weight loss profile, pH change, scanning electron microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR) study confirm the significant degradability of the scaffolds. It is observed that a 50:50_CaP/BC-PVP scaffold has the highest degree of degradation. On the other hand, the compressive strengths of CaP/BC-PVP hydrogel scaffolds are found between 0.21 to 0.31 MPa, which is comparable with the human trabecular bone. The cell viability study is performed with a human osteosarcoma Saos-2 cell line, where significant cell viability is observed in all the hydrogel scaffolds. This indicated their ability to facilitate cell growth and cell proliferation. Considering all these substantial properties, CaP/BC-PVP hydrogel scaffolds can be suggested for detailed investigation in the context of bone regeneration application. View Full-Text
Keywords: bacterial cellulose; calcium phosphate; hydrogel scaffolds; degradation; mechanical property; bone regeneration bacterial cellulose; calcium phosphate; hydrogel scaffolds; degradation; mechanical property; bone regeneration
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MDPI and ACS Style

Basu, P.; Saha, N.; Alexandrova, R.; Saha, P. Calcium Phosphate Incorporated Bacterial Cellulose-Polyvinylpyrrolidone Based Hydrogel Scaffold: Structural Property and Cell Viability Study for Bone Regeneration Application. Polymers 2019, 11, 1821. https://doi.org/10.3390/polym11111821

AMA Style

Basu P, Saha N, Alexandrova R, Saha P. Calcium Phosphate Incorporated Bacterial Cellulose-Polyvinylpyrrolidone Based Hydrogel Scaffold: Structural Property and Cell Viability Study for Bone Regeneration Application. Polymers. 2019; 11(11):1821. https://doi.org/10.3390/polym11111821

Chicago/Turabian Style

Basu, Probal, Nabanita Saha, Radostina Alexandrova, and Petr Saha. 2019. "Calcium Phosphate Incorporated Bacterial Cellulose-Polyvinylpyrrolidone Based Hydrogel Scaffold: Structural Property and Cell Viability Study for Bone Regeneration Application" Polymers 11, no. 11: 1821. https://doi.org/10.3390/polym11111821

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