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Polymers 2019, 11(1), 39;

Morphological Transformation of Peptide Nanoassemblies through Conformational Transition of Core-forming Peptides

Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Gosyokaido-cho, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan
Author to whom correspondence should be addressed.
Received: 31 October 2018 / Revised: 13 December 2018 / Accepted: 19 December 2018 / Published: 28 December 2018
(This article belongs to the Special Issue Aromatic Polymers)
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Morphological control of nanostructures that are composed of amphiphilic di- or tri-block molecules by external stimuli broadens their applications for molecular containers, nanoreactors, and controlled release materials. In this study, triblock amphiphiles comprising oligo(ethylene glycol), oligo(l-lysine), and tetra(l-phenylalanine) were prepared for the construction of nanostructures that can transform accompanying α-to-β transition of core-forming peptides. Circular dichroic (CD) measurements showed that the triblock amphiphiles adopted different secondary structures depending on the solvent environment: they adopt β-sheet structures in aqueous solution, while α-helix structures in 25% 2,2,2-trifluoroethanol (TFE) solution under basic pH conditions. Transmission electron microscopic (TEM) observation revealed that the triblock amphiphiles formed vesicle structures in 25% TFE aq. Solvent exchange from 25% TFE to water induced morphological transformation from vesicles to arc-shaped nanostructures accompanying α-β conformational transition. The transformable nanostructures may be useful as novel smart nanomaterials for molecular containers and micro reactors. View Full-Text
Keywords: aromatic peptides; self-assembly; morphological change; secondary structure aromatic peptides; self-assembly; morphological change; secondary structure

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Waku, T.; Hirata, N.; Nozaki, M.; Nogami, K.; Kunugi, S.; Tanaka, N. Morphological Transformation of Peptide Nanoassemblies through Conformational Transition of Core-forming Peptides. Polymers 2019, 11, 39.

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